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• W4233651354 startingPage "9332" @default.
• W4233651354 abstract "Abstract Kinetically inert metal complexes have arisen as promising alternatives to existing platinum and ruthenium chemotherapeutics. Reported herein, to our knowledge, is the first example of a substitutionally inert, Group 9 organometallic compound as a direct inhibitor of signal transducer and activator of transcription 3 (STAT3) dimerization. From a series of cyclometalated rhodium(III) and iridium(III) complexes, a rhodium(III) complex emerged as a potent inhibitor of STAT3 that targeted the SH2 domain and inhibited STAT3 phosphorylation and dimerization. Significantly, the complex exhibited potent anti‐tumor activities in an in vivo mouse xenograft model of melanoma. This study demonstrates that rhodium complexes may be developed as effective STAT3 inhibitors with potent anti‐tumor activity." @default.
• W4233651354 created "2022-05-12" @default.
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• W4233651354 date "2014-05-30" @default.
• W4233651354 modified "2023-10-18" @default.
• W4233651354 title "Antagonizing STAT3 Dimerization with a Rhodium(III) Complex" @default.
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• W4233651354 doi "https://doi.org/10.1002/ange.201404686" @default.
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