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• W4233651437 abstract "The four 16-hydroxymethylestra-1,3,5(10)-triene-3,17-diol isomers were synthesized and tested in a radioligand-binding assay. The estrogen receptor recognizes these compounds, but their relative binding affinities are lower than 2.0% relative to that of the reference molecule estra-1,3,5(10)-triene-3,17beta-diol. The affinities of the tested compounds for the androgen and progesterone receptors are very low (K(i)> 100 microm and 1 microM, respectively). The prepared 16-hydroxymethylestra-1,3,5(10)-triene-3,17-diol isomers are therefore estrogen receptor-selective molecules." @default.
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• W4233651437 date "2002-04-01" @default.
• W4233651437 modified "2023-10-02" @default.
• W4233651437 title "Synthesis and receptor-binding examination of 16-hydroxymethyl-3,17-estradiol stereoisomers" @default.
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• W4233651437 doi "https://doi.org/10.1016/s0039-128x(01)00191-x" @default.
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