FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233651510> ?p ?o ?g. }

• W4233651510 endingPage "S19" @default.
• W4233651510 startingPage "S19" @default.
• W4233651510 abstract "SBRT is the standard care for medically inoperable patients with stage I NSCLC, for a significant-survival improvement and good tolerance. RFA is also a promising minimally invasive and convenient non-surgical treatment option for small, peripheral tumors. However, it has only been evaluated in studies involving small numbers of patients and has not been directly compared with SBRT in randomized controlled trials. We performed a meta-analysis on the reported series of inoperable early stage NSCLCs treated with SBRT or RFA to compare clinical outcomes of these two techniques. Literature search was performed using MEDLINE, Embase and Cochrane Library from January 2001 to July 2012. The eligibility criteria included: (1) stage I NSCLC diagnosis, (2) medical inoperability, and (3) adequate clinic information. Studies about RFA followed by immediate resection or radiotherapy, or SBRT with BED <100 Gy, fraction dose <8 Gy were excluded. Meta-analyses were performed to obtain estimates for pooled overall survival (OS), local tumor control rates (LCR), and the adverse events. Standard errors of LCR and OS were estimated and corrected by the number of patients and median follow-up time. A total of 44 one-arm original studies were identified: 31 studies on SBRT (2767 patients) and 13 studies on RFA (328 patients). LCR (95% confidence interval) at 1, 2, 3 and 5 years for RFA was 77% (70 - 85%), 48% (37 - 58%), 55% (47 - 62%), and 42% (30 - 54%) respectively, which was significantly lower than that for SBRT: 97 % (96 - 98%), 92% (91 - 94%), 88% (86 - 90%), and 86% (85 - 88%), P<0.001. These differences were still significant even after correcting for each study's proportions of stage IA and age (P<0.001 at 1 year, 2 years and 3 years; P = 0.04 at 5 years). OS at 1-, 2-, 3- and 5-year for RFA was 85% (80-89%), 67% (61-74%), 53% (45-61%) and 32% (22-43%) respectively, compared to 85% (84-87%), 68% (66-71%), 56% (53-59%), and 40% (36-45%) for SBRT therapy (P > 0.05). In view of acute toxicity, the most frequent complication of RFA is pneumothorax, which occurs in 32% (16 - 45%) patients, required chest tube insertion in 12% (7-39%) of patients. The most frequent grade 3 or greater toxicity for SBRT is radiation pneumonitis (RP), occurring in 2.2% of patients (95%CI: 0.6-3.9%). The second frequent toxicity is rib fracture, occurring in 2.1% of patients (95%CI: 1.2-2.9%). LCR for SBRT is significantly higher than that for RFA, though OS is not different between two groups. Both SBRT and RFA are well tolerated. Therefore, at present patients should be offered RFA only if they are not candidates for SBRT. However, caution is warranted due to the relatively limited number of RFA studies." @default.
• W4233651510 created "2022-05-12" @default.
• W4233651510 creator A5000761419 @default.
• W4233651510 creator A5013706483 @default.
• W4233651510 creator A5083985853 @default.
• W4233651510 creator A5089768060 @default.
• W4233651510 date "2013-04-01" @default.
• W4233651510 modified "2023-10-13" @default.
• W4233651510 title "Comparison of the Effectiveness of Radiofrequency Ablation With Stereotactic Body Radiation Therapy in Inoperable Stage I Non-Small Cell Lung Cancer: A Systemic Review and Meta-analysis" @default.
• W4233651510 doi "https://doi.org/10.1016/j.prro.2013.01.066" @default.
• W4233651510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24674503" @default.
• W4233651510 hasPublicationYear "2013" @default.
• W4233651510 type Work @default.
• W4233651510 citedByCount "7" @default.
• W4233651510 countsByYear W42336515102015 @default.
• W4233651510 countsByYear W42336515102016 @default.
• W4233651510 countsByYear W42336515102018 @default.
• W4233651510 countsByYear W42336515102021 @default.
• W4233651510 crossrefType "journal-article" @default.
• W4233651510 hasAuthorship W4233651510A5000761419 @default.
• W4233651510 hasAuthorship W4233651510A5013706483 @default.
• W4233651510 hasAuthorship W4233651510A5083985853 @default.
• W4233651510 hasAuthorship W4233651510A5089768060 @default.
• W4233651510 hasBestOaLocation W42336515101 @default.
• W4233651510 hasConcept C126322002 @default.
• W4233651510 hasConcept C126838900 @default.
• W4233651510 hasConcept C141071460 @default.
• W4233651510 hasConcept C143998085 @default.
• W4233651510 hasConcept C146357865 @default.
• W4233651510 hasConcept C151730666 @default.
• W4233651510 hasConcept C168563851 @default.
• W4233651510 hasConcept C197934379 @default.
• W4233651510 hasConcept C2776256026 @default.
• W4233651510 hasConcept C2776478404 @default.
• W4233651510 hasConcept C2777377203 @default.
• W4233651510 hasConcept C2778902805 @default.
• W4233651510 hasConcept C2780387249 @default.
• W4233651510 hasConcept C44249647 @default.
• W4233651510 hasConcept C509974204 @default.
• W4233651510 hasConcept C71924100 @default.
• W4233651510 hasConcept C86803240 @default.
• W4233651510 hasConcept C95190672 @default.
• W4233651510 hasConceptScore W4233651510C126322002 @default.
• W4233651510 hasConceptScore W4233651510C126838900 @default.
• W4233651510 hasConceptScore W4233651510C141071460 @default.
• W4233651510 hasConceptScore W4233651510C143998085 @default.
• W4233651510 hasConceptScore W4233651510C146357865 @default.
• W4233651510 hasConceptScore W4233651510C151730666 @default.
• W4233651510 hasConceptScore W4233651510C168563851 @default.
• W4233651510 hasConceptScore W4233651510C197934379 @default.
• W4233651510 hasConceptScore W4233651510C2776256026 @default.
• W4233651510 hasConceptScore W4233651510C2776478404 @default.
• W4233651510 hasConceptScore W4233651510C2777377203 @default.
• W4233651510 hasConceptScore W4233651510C2778902805 @default.
• W4233651510 hasConceptScore W4233651510C2780387249 @default.
• W4233651510 hasConceptScore W4233651510C44249647 @default.
• W4233651510 hasConceptScore W4233651510C509974204 @default.
• W4233651510 hasConceptScore W4233651510C71924100 @default.
• W4233651510 hasConceptScore W4233651510C86803240 @default.
• W4233651510 hasConceptScore W4233651510C95190672 @default.
• W4233651510 hasIssue "2" @default.
• W4233651510 hasLocation W42336515101 @default.
• W4233651510 hasLocation W42336515102 @default.
• W4233651510 hasOpenAccess W4233651510 @default.
• W4233651510 hasPrimaryLocation W42336515101 @default.
• W4233651510 hasRelatedWork W2053391223 @default.
• W4233651510 hasRelatedWork W2094000083 @default.
• W4233651510 hasRelatedWork W2381982637 @default.
• W4233651510 hasRelatedWork W2531052508 @default.
• W4233651510 hasRelatedWork W2731821507 @default.
• W4233651510 hasRelatedWork W2748167152 @default.
• W4233651510 hasRelatedWork W2914141471 @default.
• W4233651510 hasRelatedWork W3029323012 @default.
• W4233651510 hasRelatedWork W3036326648 @default.
• W4233651510 hasRelatedWork W3184425712 @default.
• W4233651510 hasVolume "3" @default.
• W4233651510 isParatext "false" @default.
• W4233651510 isRetracted "false" @default.
• W4233651510 workType "article" @default.