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- W4233653031 abstract "BCG is the only available tuberculosis vaccine, but does not provide complete or durable protection. Recently, researchers evaluated the ability of the experimental vaccine Mtb72F/AS02A, which contains two Mycobacterium tuberculosis proteins (Mtb32 and Mtb39) and the adjuvant AS02A, to protect cynomolgus monkeys against tuberculosis. They report that a prime–boost protocol in which immunisation with BCG is followed by immunisation with Mtb72F/AS02A induces better long-term protection against disease and death in monkeys infected with M tuberculosis than either vaccine alone. Moving closer to a new tuberculosis vaccineThis month sees the start of a phase IIb proof-of-concept efficacy trial of the MVA85A candidate tuberculosis vaccine in around 2800 infants at the South African Tuberculosis Vaccine Initiative field site in Worcester, Western Cape, South Africa. Clinical trials of other candidates are also underway , and it seems possible that the first new tuberculosis vaccine for nearly 90 years could be available in less than a decade. Full-Text PDF" @default.
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- W4233653031 date "2009-03-01" @default.
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- W4233653031 title "Research brief" @default.
- W4233653031 doi "https://doi.org/10.1016/s1473-3099(09)70037-4" @default.
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