Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233657750> ?p ?o ?g. }
Showing items 1 to 40 of
40
with 100 items per page.
- W4233657750 endingPage "1307" @default.
- W4233657750 startingPage "1307" @default.
- W4233657750 abstract "The ability of Ag-primed B cells to recruit distinct Th subsets was examined using two analogous synthetic peptides, G41CT3 and G28CT3, as model Ags. With sequence differences at only two positions, these peptides were identical both with respect to fine specificity of Abs induced and ability to prime T cells. Lymph node cell populations primed with peptide G41CT3, when challenged with the homologous Ag, yielded predominantly Th2 cytokines. In contrast, a challenge with the heterologous Ag, G28CT3, resulted in a markedly increased production of Th1 cytokines. These distinctions derived from altered APC function of Ag-primed B cells due to differential kinetics of recognition of the two Ags by surface Ig receptors, as confirmed by binding studies with a panel of anti-G41CT3 mAbs. A concentration-dependent circular dichroism study revealed differences in the nature of intermolecular associations for these two peptides. Furthermore, the on-rate of peptide G28CT3 binding to Ab also increased with increasing peptide concentration, implying a dependence on intermolecular interactions. This, in turn, correlated well with the ability of peptide G28CT3 to preferentially activate either Th1 or Th2 cells. Thus, the relative proportion of Th1 vs Th2 cells recruited by Ag-primed B cells is governed by the on-rate of Ag binding to surface Ig receptors, with higher on-rates promoting Th1 recruitment. Further, even subtle changes in solution behavior of an Ag can markedly influence the kinetics of recognition by B cells." @default.
- W4233657750 created "2022-05-12" @default.
- W4233657750 creator A5038894623 @default.
- W4233657750 date "1994-11-12" @default.
- W4233657750 modified "2023-09-26" @default.
- W4233657750 title "Young bones" @default.
- W4233657750 doi "https://doi.org/10.1136/bmj.309.6964.1307" @default.
- W4233657750 hasPublicationYear "1994" @default.
- W4233657750 type Work @default.
- W4233657750 citedByCount "0" @default.
- W4233657750 crossrefType "journal-article" @default.
- W4233657750 hasAuthorship W4233657750A5038894623 @default.
- W4233657750 hasConcept C136764020 @default.
- W4233657750 hasConcept C2522767166 @default.
- W4233657750 hasConcept C41008148 @default.
- W4233657750 hasConcept C71924100 @default.
- W4233657750 hasConceptScore W4233657750C136764020 @default.
- W4233657750 hasConceptScore W4233657750C2522767166 @default.
- W4233657750 hasConceptScore W4233657750C41008148 @default.
- W4233657750 hasConceptScore W4233657750C71924100 @default.
- W4233657750 hasIssue "6964" @default.
- W4233657750 hasLocation W42336577501 @default.
- W4233657750 hasOpenAccess W4233657750 @default.
- W4233657750 hasPrimaryLocation W42336577501 @default.
- W4233657750 hasRelatedWork W1506200166 @default.
- W4233657750 hasRelatedWork W1995515455 @default.
- W4233657750 hasRelatedWork W2048182022 @default.
- W4233657750 hasRelatedWork W2080531066 @default.
- W4233657750 hasRelatedWork W2323581027 @default.
- W4233657750 hasRelatedWork W2748952813 @default.
- W4233657750 hasRelatedWork W2899084033 @default.
- W4233657750 hasRelatedWork W3031052312 @default.
- W4233657750 hasRelatedWork W3032375762 @default.
- W4233657750 hasRelatedWork W3108674512 @default.
- W4233657750 hasVolume "309" @default.
- W4233657750 isParatext "false" @default.
- W4233657750 isRetracted "false" @default.
- W4233657750 workType "article" @default.