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• W4233670290 abstract "Concerning our study,1 we would like to thank Dr's Palma and Pickles for their letter, which validates the association they2 noted in men who have Gleason score 8 to 10 prostate cancers. Specifically, after adjusting for known prognostic factors, we noted a significant association between the risk of prostate-cancer–specific mortality and the time to testosterone rebound (TTR) in men who were undergoing radiation therapy and 6 months of hormonal therapy for prostate cancer. Lending further support to this association are results of the European Organization for Research in the Treatment of Cancer randomized trial,3 which compared radiation therapy and 3 years of hormone therapy to radiation therapy and 6 months of hormone therapy. Whereas the equivalence of overall survival between the 2 randomized treatment arms was not shown, superiority was also not shown, thus suggesting that some, but not all, men benefited from 3 years of hormone therapy. Because the median age was 69 years, it is possible that only the younger men may have benefited as their TTR after 6 months of hormone therapy would be expected to be shorter than that of the older men.1 This hypothesis has generated a subgroup analysis, which is underway. Moreover, a report4 from an analysis of Radiation Therapy Oncology Group trials has shown a significant association between a shorter time to metastasis and younger age after adjusting for hormone therapy duration and known prognostic factors. Therefore, although a prospective study proving causation is needed, it appears that survival time is determined by the length of testosterone suppression and not simply the length of hormone therapy administration. Anthony V. D'Amico MD*, Ming-Hui Chen PhD , * Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts, Department of Statistics, University of Connecticut, Storrs, Connecticut." @default.
• W4233670290 created "2022-05-12" @default.
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• W4233670290 date "2008-03-07" @default.
• W4233670290 modified "2023-10-15" @default.
• W4233670290 title "Reply to Duration of Testosterone Suppression and the Risk of Death from Prostate Cancer in Men Treated Using Radiation and 6 Months of Hormone Therapy" @default.
• W4233670290 cites W2010627375 @default.
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• W4233670290 doi "https://doi.org/10.1002/cncr.23426" @default.
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