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• W4233752026 abstract "Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that bicaudal D homolog 1, encoded by BICD1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. BICD1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of BICD1 in primary tumors was correlated with patient distant metastasis-free survival. Modulation of BICD1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer." @default.
• W4233752026 created "2022-05-12" @default.
• W4233752026 creator A5024900493 @default.
• W4233752026 date "2021-02-11" @default.
• W4233752026 modified "2023-10-18" @default.
• W4233752026 title "BICD1 is a differentially expressed gene in brain metastatic human breast cancer." @default.
• W4233752026 doi "https://doi.org/10.31219/osf.io/ycxam" @default.
• W4233752026 hasPublicationYear "2021" @default.
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