Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233770102> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4233770102 endingPage "45" @default.
- W4233770102 startingPage "40" @default.
- W4233770102 abstract "The proto-oncogene Ets-1 is a transcription factor known to regulate the expression of a number of genes involved in extracellular matrix remodelling. It has been postulated to play a role in angiogenesis, cell migration, and regulation of tumour invasion. In betel and tobacco-related oral tumourigenesis, oral squamous cell carcinomas (SCCs) having a poor prognosis often exhibit extensive local disease with spread into regional lymph nodes. At present, no tumour marker is available to predict the metastatic potential of oral carcinomas. To elucidate the involvement of Ets-1 in human oral tumourigenesis, 60 cases of oral SCC, 30 potentially malignant lesions, and 30 samples of normal oral mucosa were examined by immunohistochemistry and the findings corroborated with immunoblotting. The relationship of Ets-1 expression with the degree of differentiation, lymph node metastasis, and tumour stage was determined in oral SCCs. Ets-1 was not detected in the normal oral epithelium. Among the 60 cases of oral SCC, 35 cases (58 per cent) showed positive staining for the Ets-1 protein in tumour cells. In potentially malignant lesions, 14 of 30 cases (47 per cent) showed Ets-1 immunopositivity. Ets-1 expression correlated significantly with tumour stage ( p=0.01) and lymph node metastasis ( p=0.005). The presence of Ets-1 mRNA in oral SCCs was confirmed by reverse transcription-polymerase chain reaction (RT-PCR). These findings suggest that overexpression of Ets-1 in potentially malignant lesions may be related to angiogenesis and its expression in oral SCCs may be one of the factors involved in tumour progression and lymph node metastasis." @default.
- W4233770102 created "2022-05-12" @default.
- W4233770102 creator A5050945412 @default.
- W4233770102 creator A5054229964 @default.
- W4233770102 creator A5056782240 @default.
- W4233770102 creator A5073536500 @default.
- W4233770102 date "1999-09-01" @default.
- W4233770102 modified "2023-09-25" @default.
- W4233770102 title "Ets-1: a plausible marker of invasive potential and lymph node metastasis in human oral squamous cell carcinomas" @default.
- W4233770102 cites W1965218076 @default.
- W4233770102 cites W1967004332 @default.
- W4233770102 cites W2003333623 @default.
- W4233770102 cites W2011487859 @default.
- W4233770102 cites W2012958068 @default.
- W4233770102 cites W2044924927 @default.
- W4233770102 cites W204536596 @default.
- W4233770102 cites W2065647828 @default.
- W4233770102 cites W2068571186 @default.
- W4233770102 cites W2071319763 @default.
- W4233770102 cites W2071335464 @default.
- W4233770102 cites W2089813796 @default.
- W4233770102 cites W2120789358 @default.
- W4233770102 cites W2127580144 @default.
- W4233770102 cites W2129941826 @default.
- W4233770102 cites W30214070 @default.
- W4233770102 cites W4230137931 @default.
- W4233770102 doi "https://doi.org/10.1002/(sici)1096-9896(199909)189:1<40::aid-path405>3.0.co;2-" @default.
- W4233770102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10451486" @default.
- W4233770102 hasPublicationYear "1999" @default.
- W4233770102 type Work @default.
- W4233770102 citedByCount "52" @default.
- W4233770102 countsByYear W42337701022012 @default.
- W4233770102 countsByYear W42337701022013 @default.
- W4233770102 countsByYear W42337701022014 @default.
- W4233770102 countsByYear W42337701022015 @default.
- W4233770102 countsByYear W42337701022016 @default.
- W4233770102 countsByYear W42337701022017 @default.
- W4233770102 countsByYear W42337701022018 @default.
- W4233770102 countsByYear W42337701022019 @default.
- W4233770102 countsByYear W42337701022023 @default.
- W4233770102 crossrefType "journal-article" @default.
- W4233770102 hasAuthorship W4233770102A5050945412 @default.
- W4233770102 hasAuthorship W4233770102A5054229964 @default.
- W4233770102 hasAuthorship W4233770102A5056782240 @default.
- W4233770102 hasAuthorship W4233770102A5073536500 @default.
- W4233770102 hasConcept C121608353 @default.
- W4233770102 hasConcept C126322002 @default.
- W4233770102 hasConcept C142724271 @default.
- W4233770102 hasConcept C1491633281 @default.
- W4233770102 hasConcept C204232928 @default.
- W4233770102 hasConcept C2777546739 @default.
- W4233770102 hasConcept C2779013556 @default.
- W4233770102 hasConcept C2779409057 @default.
- W4233770102 hasConcept C2780394083 @default.
- W4233770102 hasConcept C2780849966 @default.
- W4233770102 hasConcept C2781018059 @default.
- W4233770102 hasConcept C29537977 @default.
- W4233770102 hasConcept C2994460389 @default.
- W4233770102 hasConcept C502942594 @default.
- W4233770102 hasConcept C54355233 @default.
- W4233770102 hasConcept C71924100 @default.
- W4233770102 hasConcept C86803240 @default.
- W4233770102 hasConceptScore W4233770102C121608353 @default.
- W4233770102 hasConceptScore W4233770102C126322002 @default.
- W4233770102 hasConceptScore W4233770102C142724271 @default.
- W4233770102 hasConceptScore W4233770102C1491633281 @default.
- W4233770102 hasConceptScore W4233770102C204232928 @default.
- W4233770102 hasConceptScore W4233770102C2777546739 @default.
- W4233770102 hasConceptScore W4233770102C2779013556 @default.
- W4233770102 hasConceptScore W4233770102C2779409057 @default.
- W4233770102 hasConceptScore W4233770102C2780394083 @default.
- W4233770102 hasConceptScore W4233770102C2780849966 @default.
- W4233770102 hasConceptScore W4233770102C2781018059 @default.
- W4233770102 hasConceptScore W4233770102C29537977 @default.
- W4233770102 hasConceptScore W4233770102C2994460389 @default.
- W4233770102 hasConceptScore W4233770102C502942594 @default.
- W4233770102 hasConceptScore W4233770102C54355233 @default.
- W4233770102 hasConceptScore W4233770102C71924100 @default.
- W4233770102 hasConceptScore W4233770102C86803240 @default.
- W4233770102 hasIssue "1" @default.
- W4233770102 hasLocation W42337701021 @default.
- W4233770102 hasLocation W42337701022 @default.
- W4233770102 hasOpenAccess W4233770102 @default.
- W4233770102 hasPrimaryLocation W42337701021 @default.
- W4233770102 hasRelatedWork W2358524972 @default.
- W4233770102 hasRelatedWork W2522447413 @default.
- W4233770102 hasRelatedWork W2762132287 @default.
- W4233770102 hasRelatedWork W2791088259 @default.
- W4233770102 hasRelatedWork W2792929645 @default.
- W4233770102 hasRelatedWork W2998402275 @default.
- W4233770102 hasRelatedWork W3114532332 @default.
- W4233770102 hasRelatedWork W3173207637 @default.
- W4233770102 hasRelatedWork W3175984978 @default.
- W4233770102 hasRelatedWork W4311669536 @default.
- W4233770102 hasVolume "189" @default.
- W4233770102 isParatext "false" @default.
- W4233770102 isRetracted "false" @default.
- W4233770102 workType "article" @default.