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- W4233820797 endingPage "256" @default.
- W4233820797 startingPage "245" @default.
- W4233820797 abstract "Reconstruction of extensive bone defects remains technically challenging and has considerable medical and financial impact on our society. Surgical procedures often require a bone/substitute graft to enhance and accelerate bone repair. Bone autografts are associated with morbidity related to bone harvesting and are limited in quantity. Alternatively, bone allografts expose the patient to the risk of transmission of infectious disease. Synthetic bone graft substitutes, such as calcium sulfates, hydroxyapatite, tricalcium phosphate, and combinations, circumvent some of the disadvantages of auto- and allografts, but have limited indications. Biomedical research has made possible the stimulation of the body’s own healing mechanisms, either by delivering exogenous growth factors locally, or by stimulating their local production by gene transfer. Among all known factors having osteoinductive properties, only two bone morphogenetic proteins (for specific indications) and demineralized bone matrix have been approved for clinical use. In addition, ongoing research is exploring the efficacy of cell therapy and tissue engineering. The present report examines the composition, biological properties, indications, clinical experience and regulations of several of the biotherapeutics employed for bone reconstruction." @default.
- W4233820797 created "2022-05-12" @default.
- W4233820797 creator A5007696346 @default.
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- W4233820797 creator A5053817793 @default.
- W4233820797 creator A5068309045 @default.
- W4233820797 creator A5078683324 @default.
- W4233820797 date "2012-08-01" @default.
- W4233820797 modified "2023-10-10" @default.
- W4233820797 title "Recommendations and Considerations for the Use of Biologics in Orthopedic Surgery" @default.
- W4233820797 cites W1223088827 @default.
- W4233820797 cites W1534731743 @default.
- W4233820797 cites W1541207461 @default.
- W4233820797 cites W174364120 @default.
- W4233820797 cites W1900874282 @default.
- W4233820797 cites W1942341118 @default.
- W4233820797 cites W1963901817 @default.
- W4233820797 cites W1965676278 @default.
- W4233820797 cites W1965815905 @default.
- W4233820797 cites W1965820107 @default.
- W4233820797 cites W1966994557 @default.
- W4233820797 cites W1967146478 @default.
- W4233820797 cites W1968822620 @default.
- W4233820797 cites W1975775804 @default.
- W4233820797 cites W1976584345 @default.
- W4233820797 cites W1977907258 @default.
- W4233820797 cites W1978109374 @default.
- W4233820797 cites W1978498660 @default.
- W4233820797 cites W1982337258 @default.
- W4233820797 cites W1982831132 @default.
- W4233820797 cites W1983942154 @default.
- W4233820797 cites W1984598308 @default.
- W4233820797 cites W1984743383 @default.
- W4233820797 cites W1985222459 @default.
- W4233820797 cites W1986425697 @default.
- W4233820797 cites W1987621221 @default.
- W4233820797 cites W1988258971 @default.
- W4233820797 cites W1988423180 @default.
- W4233820797 cites W1988592246 @default.
- W4233820797 cites W1989179000 @default.
- W4233820797 cites W1990259874 @default.
- W4233820797 cites W1991163303 @default.
- W4233820797 cites W1991350431 @default.
- W4233820797 cites W1992006010 @default.
- W4233820797 cites W1992647962 @default.
- W4233820797 cites W1993799862 @default.
- W4233820797 cites W1994169116 @default.
- W4233820797 cites W1997421419 @default.
- W4233820797 cites W1997491556 @default.
- W4233820797 cites W1998002551 @default.
- W4233820797 cites W1998169435 @default.
- W4233820797 cites W2001619703 @default.
- W4233820797 cites W2001788240 @default.
- W4233820797 cites W2002928584 @default.
- W4233820797 cites W2004337957 @default.
- W4233820797 cites W2006682301 @default.
- W4233820797 cites W2009487921 @default.
- W4233820797 cites W2009743923 @default.
- W4233820797 cites W2020523827 @default.
- W4233820797 cites W2023258643 @default.
- W4233820797 cites W2024008035 @default.
- W4233820797 cites W2029542498 @default.
- W4233820797 cites W2031146748 @default.
- W4233820797 cites W2031380373 @default.
- W4233820797 cites W2032432334 @default.
- W4233820797 cites W2032678092 @default.
- W4233820797 cites W2034148679 @default.
- W4233820797 cites W2036450265 @default.
- W4233820797 cites W2036623860 @default.
- W4233820797 cites W2039186421 @default.
- W4233820797 cites W2039485745 @default.
- W4233820797 cites W2039749728 @default.
- W4233820797 cites W2039897133 @default.
- W4233820797 cites W2040255393 @default.
- W4233820797 cites W2043303130 @default.
- W4233820797 cites W2044073033 @default.
- W4233820797 cites W2044502023 @default.
- W4233820797 cites W2044951287 @default.
- W4233820797 cites W2045383620 @default.
- W4233820797 cites W2045604070 @default.
- W4233820797 cites W2046290393 @default.
- W4233820797 cites W2046563190 @default.
- W4233820797 cites W2047292103 @default.
- W4233820797 cites W2047722298 @default.
- W4233820797 cites W2049621461 @default.
- W4233820797 cites W2049646476 @default.
- W4233820797 cites W205069425 @default.
- W4233820797 cites W2052938715 @default.
- W4233820797 cites W2055110769 @default.
- W4233820797 cites W2056571568 @default.
- W4233820797 cites W2057315313 @default.
- W4233820797 cites W2060416200 @default.
- W4233820797 cites W2060944528 @default.
- W4233820797 cites W2061981400 @default.
- W4233820797 cites W2064409905 @default.
- W4233820797 cites W2067386137 @default.
- W4233820797 cites W2067560105 @default.