Matches in SemOpenAlex for { <https://semopenalex.org/work/W4233957863> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4233957863 endingPage "959" @default.
- W4233957863 startingPage "953" @default.
- W4233957863 abstract "Background : Serotonergic (5-HT) dysfunction has been implicated in the etiology of both behavioral disinhibition (BD) and negative affect (NA). This work extends our previous finding of relationships between whole blood 5-HT and both BD and NA in pubescent, but not prepubescent, children of alcoholics and continues examination of a hypothesized role of 5-HT dysfunction in alcoholism risk. The long and short (L and S) variants of the 5-HT transporter gene-linked polymorphic region (5-HTTLPR) are responsible for differing transcriptional efficiencies in 5-HT uptake. Although associations have been found between the SS 5-HTTLPR genotype and severe alcoholism and neuroticism, recent reports describe relationships between the LL genotype and both low level of response to alcohol and alcoholism diagnosis and a predominance of the LL genotype in early-onset alcoholics. Methods: This report is from an ongoing prospective study of the development of risk for alcoholism and other problematic outcomes in a sample of families classified by father's alcoholism subtype. This study examines relationships between 5-HTTLPR genotype and both child BD (Child Behavior Checklist Aggressive Behavior) and NA (Child Behavior Checklist Anxious/Depressed) in offspring from 47 families. Results: Results showed significantly higher levels of BD and NA in the 16 children with the LL genotype than the 46 SS or SL children. Conclusions: Behaviors of undercontrol, which occur at increased rates in children of alcoholics, may be genetically influenced through the regulation of the 5-HT transporter. Due to the small sample size and the preliminary nature of our findings, replication is necessary." @default.
- W4233957863 created "2022-05-12" @default.
- W4233957863 creator A5002090056 @default.
- W4233957863 creator A5022193838 @default.
- W4233957863 creator A5027815153 @default.
- W4233957863 creator A5070368893 @default.
- W4233957863 creator A5077464290 @default.
- W4233957863 creator A5080995779 @default.
- W4233957863 date "2001-07-01" @default.
- W4233957863 modified "2023-10-12" @default.
- W4233957863 title "Serotonin Transporter Promoter Polymorphism Genotype Is Associated With Behavioral Disinhibition and Negative Affect in Children of Alcoholics" @default.
- W4233957863 doi "https://doi.org/10.1097/00000374-200107000-00002" @default.
- W4233957863 hasPublicationYear "2001" @default.
- W4233957863 type Work @default.
- W4233957863 citedByCount "0" @default.
- W4233957863 crossrefType "journal-article" @default.
- W4233957863 hasAuthorship W4233957863A5002090056 @default.
- W4233957863 hasAuthorship W4233957863A5022193838 @default.
- W4233957863 hasAuthorship W4233957863A5027815153 @default.
- W4233957863 hasAuthorship W4233957863A5070368893 @default.
- W4233957863 hasAuthorship W4233957863A5077464290 @default.
- W4233957863 hasAuthorship W4233957863A5080995779 @default.
- W4233957863 hasBestOaLocation W42339578632 @default.
- W4233957863 hasConcept C104317684 @default.
- W4233957863 hasConcept C112672928 @default.
- W4233957863 hasConcept C118552586 @default.
- W4233957863 hasConcept C126322002 @default.
- W4233957863 hasConcept C135763542 @default.
- W4233957863 hasConcept C149737253 @default.
- W4233957863 hasConcept C15744967 @default.
- W4233957863 hasConcept C170493617 @default.
- W4233957863 hasConcept C187288502 @default.
- W4233957863 hasConcept C2775864247 @default.
- W4233957863 hasConcept C2776035688 @default.
- W4233957863 hasConcept C2776599063 @default.
- W4233957863 hasConcept C2778897192 @default.
- W4233957863 hasConcept C2779234561 @default.
- W4233957863 hasConcept C2781192327 @default.
- W4233957863 hasConcept C37000724 @default.
- W4233957863 hasConcept C46312422 @default.
- W4233957863 hasConcept C54355233 @default.
- W4233957863 hasConcept C70410870 @default.
- W4233957863 hasConcept C71924100 @default.
- W4233957863 hasConcept C77805123 @default.
- W4233957863 hasConcept C86803240 @default.
- W4233957863 hasConcept C94612546 @default.
- W4233957863 hasConceptScore W4233957863C104317684 @default.
- W4233957863 hasConceptScore W4233957863C112672928 @default.
- W4233957863 hasConceptScore W4233957863C118552586 @default.
- W4233957863 hasConceptScore W4233957863C126322002 @default.
- W4233957863 hasConceptScore W4233957863C135763542 @default.
- W4233957863 hasConceptScore W4233957863C149737253 @default.
- W4233957863 hasConceptScore W4233957863C15744967 @default.
- W4233957863 hasConceptScore W4233957863C170493617 @default.
- W4233957863 hasConceptScore W4233957863C187288502 @default.
- W4233957863 hasConceptScore W4233957863C2775864247 @default.
- W4233957863 hasConceptScore W4233957863C2776035688 @default.
- W4233957863 hasConceptScore W4233957863C2776599063 @default.
- W4233957863 hasConceptScore W4233957863C2778897192 @default.
- W4233957863 hasConceptScore W4233957863C2779234561 @default.
- W4233957863 hasConceptScore W4233957863C2781192327 @default.
- W4233957863 hasConceptScore W4233957863C37000724 @default.
- W4233957863 hasConceptScore W4233957863C46312422 @default.
- W4233957863 hasConceptScore W4233957863C54355233 @default.
- W4233957863 hasConceptScore W4233957863C70410870 @default.
- W4233957863 hasConceptScore W4233957863C71924100 @default.
- W4233957863 hasConceptScore W4233957863C77805123 @default.
- W4233957863 hasConceptScore W4233957863C86803240 @default.
- W4233957863 hasConceptScore W4233957863C94612546 @default.
- W4233957863 hasIssue "7" @default.
- W4233957863 hasLocation W42339578631 @default.
- W4233957863 hasLocation W42339578632 @default.
- W4233957863 hasLocation W42339578633 @default.
- W4233957863 hasOpenAccess W4233957863 @default.
- W4233957863 hasPrimaryLocation W42339578631 @default.
- W4233957863 hasRelatedWork W1965033433 @default.
- W4233957863 hasRelatedWork W1979014186 @default.
- W4233957863 hasRelatedWork W2054579518 @default.
- W4233957863 hasRelatedWork W2126307255 @default.
- W4233957863 hasRelatedWork W2156074396 @default.
- W4233957863 hasRelatedWork W2166137433 @default.
- W4233957863 hasRelatedWork W2361402747 @default.
- W4233957863 hasRelatedWork W2383064192 @default.
- W4233957863 hasRelatedWork W2743107162 @default.
- W4233957863 hasRelatedWork W2896869106 @default.
- W4233957863 hasVolume "25" @default.
- W4233957863 isParatext "false" @default.
- W4233957863 isRetracted "false" @default.
- W4233957863 workType "article" @default.