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- W4233999914 abstract "In 1797 William Hyde Wollaston (1766-1828) announced that the principal constituent of gouty concretions (tophi) was a neutral compound consisting of lithic acid [uric acid]... and mineral alkali. To many this evidence was sufficient to answer the centuries-old question concerning the<i>materies morbi</i>of the gout. Others, however, remained unconvinced, troubled by the failure to demonstrate this substance in the blood. Might not the kidney be the original source of the uric acid found in normal urine and in renal calculae, and might not the presence of sodium urate in tophi be the result of local production secondary to inflammation? The solutions to these and many other fundamental questions were provided by Alfred Baring Garrod, FRS (1819-1907), whose researches on the relationship between uric acid and the gout constitute the basis of modern understanding of the disease.<sup>1-6</sup> In 1848 Garrod, then a young assistant physician at the University" @default.
- W4233999914 created "2022-05-12" @default.
- W4233999914 date "1973-04-30" @default.
- W4233999914 modified "2023-09-25" @default.
- W4233999914 title "Cover Story: Sir Alfred Baring Garrod, FRS" @default.
- W4233999914 doi "https://doi.org/10.1001/jama.224.suppl_5.663" @default.
- W4233999914 hasPublicationYear "1973" @default.
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