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- W4234012687 abstract "Background Multifocal motor neuropathy is characterised by progressive, predominantly distal, asymmetrical limb weakness and usually multiple partial motor nerve conduction blocks. Intravenous immunoglobulin is beneficial but the role of immunosuppressive agents is uncertain. Objectives To provide the best available evidence from randomised controlled trials on the role of immunosuppressive agents for the treatment of multifocal motor neuropathy. Search methods For this update, we searched the Cochrane Neuromuscular Disease Group Trials Register (October 8 2008), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, Issue 4), MEDLINE (from January 1966 to October 8 2008), and EMBASE (from January 1980 to October 8 2008), for trials of multifocal motor neuropathy. Selection criteria Randomised and quasi‐randomised controlled trials were to be included and one was found. Prospective and retrospective case series and case reports were considered in the Discussion. Data collection and analysis Two review authors searched the titles and abstracts of the articles identified and extracted the data independently. Main results In this update, we found the first randomised controlled trial of multifocal motor neuropathy. This study, which randomised 28 patients, showed that mycophenolate mofetil did not significantly improve strength or function or reduce the need for intravenous immunoglobulin. We summarised the results of retrospective and prospective case series in the discussion. Authors' conclusions In the only randomised placebo‐controlled trial of any immunosuppressive agent, mycophenolate mofetil did not produce significant benefit. Trials of other immunosuppressants should be undertaken." @default.
- W4234012687 created "2022-05-12" @default.
- W4234012687 creator A5015980732 @default.
- W4234012687 creator A5032510994 @default.
- W4234012687 creator A5049139387 @default.
- W4234012687 creator A5053578374 @default.
- W4234012687 date "2009-01-21" @default.
- W4234012687 modified "2023-09-30" @default.
- W4234012687 title "Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy" @default.
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