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- W4234030496 abstract "In daily clinical settings, drug choice most commonly ends in two variants: physician lefts unchanged previously prescribed therapy and does not titer dosages, or recommends less expensive medication instead. A myriad of brand-name and generic cardiologic medicines has led to the fact that physicians group drugs by their class effect but forget that any drug is characterized by specific pharmacokinetics, pharmacodynamics, and effects on target organs. Grouping by class effect results in an unreasonable change to less effective medication. The diversity of pharmacokinetics, pharmacodynamics, and organ protection is particularly clear in a group of angiotensin-converting enzyme (ACE) inhibitors. This paper describes in detail the characteristics and clinical effects of ACE inhibitors. Pharmacological properties and clinical characteristics of fosinopril are emphasized. This paper also addresses clinical studies on ACE inhibitors which allow for rational drug choice at any stage of the cardiovascular continuum. KEYWORDS: ACE inhibitors, hypertension, proteinuria, atherosclerosis, diabetes. FOR CITATION: Fomin I.V., Vinogradova N.G. Angiotensin-converting enzyme inhibitors at the stages of the cardiovascular continuum: missed opportunities and real prospects. Russian Medical Inquiry. 2021;5(4):225–231 (in Russ.). DOI: 10.32364/2587-6821-2021-5-4-225-231." @default.
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- W4234030496 date "2021-01-01" @default.
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- W4234030496 title "Angiotensin-converting enzyme inhibitors at the stages of the cardiovascular continuum: missed opportunities and real prospects" @default.
- W4234030496 doi "https://doi.org/10.32364/2587-6821-2021-5-4-225-231" @default.
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