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- W4234037995 abstract "Abstract Background The relationship between growth differentiation factor 15 (GDF-15) and the development of chronic kidney disease (CKD) is still unclear. We sought to examine whether plasma GDF-15 was related to incident CKD and kidney function decline using a large prospective cohort study. Methods 4,318 participants of the Malmö Diet and Cancer Study-Cardiovascular Cohort were examined in 1991–1994 and followed prospectively until 2013 for incidence of CKD, as detected from national registers. Estimated glomerular filtration rate (eGFR) was available for all participants at baseline, and was re-measured in a subgroup of 2,744 subjects after 16.6 ± 1.49 years. Incidence of CKD was examined in relation to GDF-15 using Cox regression analysis. Logistic regression was used to examine the association of GDF-15 with eGFR change and eGFR-based CKD. Models were carefully corrected for potential confounders including baseline eGFR, N-terminal pro-B-type natriuretic peptide, and competing risk from death. Results 165 patients developed CKD after 19.2 ± 4.04 years of follow-up. The adjusted hazard ratio (95% confidence interval, CI) for CKD in 4th versus 1st quartile of GDF-15 was 2.37 (1.33, 4.24) ( p for trend < 0.01). Each per 1 standard deviation increase in GDF-15 was associated with a decline in eGFR of -0.97 mL/min/1.73 m 2 (95% CI, -1.49~-0.45; p < 0.001). GDF-15 was also significantly associated eGFR-based CKD in 2,713 subjects with baseline eGFR ≥ 60 mL/min/1.73 m 2 . Conclusions GDF-15 predicted incidence of CKD and eGFR decline in the general population, independent of a wide range of potential risk factors and competing risk of death." @default.
- W4234037995 created "2022-05-12" @default.
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- W4234037995 date "2021-04-08" @default.
- W4234037995 modified "2023-10-17" @default.
- W4234037995 title "Growth Differentiation Factor-15 and Incident Chronic Kidney Disease: A Population-Based Cohort Study" @default.
- W4234037995 doi "https://doi.org/10.21203/rs.3.rs-394958/v1" @default.
- W4234037995 hasPublicationYear "2021" @default.
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