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- W4234133592 abstract "Preclinical studies have demonstrated synergistic actions of specific nutrients, leading to increased formation of synaptic membrane, reduced Abeta production, and improved memory. Based on these findings, a multi-nutrient concept known as Fortasyn™ Connect (FC) was designed for AD patients. The medical food Souvenaid® containing FC was tested in a randomized controlled trial and showed improvement in memory in drug-naive mild AD patients. Results of this trial suggest a potential role for Souvenaid® in the overall management of AD. Current standard practice for treatment of AD, acetylcholinesterase inhibitors (AChEI) have been reported to induce common adverse events including digestive, cardiovascular, and urogenital effects. The present study in aged rats was designed to see whether Souvenaid may be used safely in concordance with AChEI, i.e. without increasing possible side effects. 24-months-old rats were fed either a diet containing FC or a Control diet and were administered increasing doses of an AChEI. Brain AChE activity was measured in addition to physiological parameters reported to be influenced by AChEI, such as body temperature (BT), heart rate, micturition and locomotor activity (LA). Administration of AChEI confirmed earlier reported reductions of brain AChE-activity. In addition, the AChEI dose-dependently reduced BT and LA, while it increased micturition. The FC diet did not have a negative effect on brain AChE activity or on any of the other physiological parameters studied. This study showing the absence of interaction between the FC diet and an AChEI on an extensive set of cholinergic parameters, provides a good starting point to evaluate the potential benefits of Souvenaid® in AD patients that receive standard pharmacological treatment in a clinical setting. Currently, Souvenaid® is being tested in such an add-on setting, the S-Connect study (NTR1683)." @default.
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- W4234133592 date "2011-07-01" @default.
- W4234133592 modified "2023-09-27" @default.
- W4234133592 title "P4-254: A novel medical food Souvenaid® for AD patients can be used safely in combination with an acetylcholinesterase inhibitor in an aged rat model" @default.
- W4234133592 doi "https://doi.org/10.1016/j.jalz.2011.05.2279" @default.
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