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- W4234161036 abstract "Clonidine hydrochloride is an imidazoline-derivative hypotensive agent that acts through the central nervous system to elicit a hypotensive response. Although the locus of action in the central nervous system is unlcear, clonidine has been shown to be a potent α-adrenergic agonist in both central and peripheral systems. The commercially available transdermal system of clonidine consists of an outer layer of pigmented polyester; a drug reservoir of clonidine, mineral oil, polyisobutylene, and colloidal silicon dioxide; a microporous polypropylene membrane, which controls the rate of diffusion of the drug; and a final adhesive layer, which provides an initial release of the drug and contains those ingredients found in the reservoir. The adhesive layer is covered by a protective strip, which is removed prior to application. Clonidine hydrochloride is a white, or almost white, crystalline powder having a bitter taste." @default.
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- W4234161036 date "1992-01-01" @default.
- W4234161036 modified "2023-10-17" @default.
- W4234161036 title "Clonidine Hydrochloride" @default.
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- W4234161036 doi "https://doi.org/10.1016/s0099-5428(08)60390-1" @default.
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