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- W4234277718 abstract "Impact of white matter abnormalities (WMAs) on neuropsychological functioning in children with early‐treated phenylketonuria (ETPKU) was examined. Children with ETPKU (20 males, 12 females, mean age 11 years 2 months, SD 3 years 6 months) and controls (20 males, 14 females, mean age 10 years 4 months, SD 3 years 1 month) aged 7 to 18 years were assessed using tests of attention, processing speed, memory and learning, executive function, and academic achievement. Those with ETPKU, exhibiting WMAs extending into subcortical/frontal regions ( n =14), displayed significant impairments in a number of domains. Children with ETPKU but no WMAs ( n =6), or pathology restricted to the posterior periventricular region ( n =12), displayed only mild deficits. Concurrent phenylalanine levels correlated weakly with cognitive parameters, whereas lifetime phenylalanine levels were associated with deficits in several cognitive domains. Impairments in children with extensive WMAs are consistent with compromised neural transmission, which is characterized by dysmyelination. However, children with no detectable, or mild WMAs, also displayed cognitive problems, indicating that neuropsychological functioning in children with ETPKU is determined by a complex interaction of biological and environmental factors." @default.
- W4234277718 created "2022-05-12" @default.
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- W4234277718 date "2004-04-01" @default.
- W4234277718 modified "2023-10-09" @default.
- W4234277718 title "Neuropsychological functioning in children with early-treated phenylketonuria: impact of white matter abnormalities" @default.
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- W4234277718 doi "https://doi.org/10.1111/j.1469-8749.2004.tb00477.x" @default.
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