FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234285465> ?p ?o ?g. }

• W4234285465 endingPage "846" @default.
• W4234285465 startingPage "831" @default.
• W4234285465 abstract "ABSTRACT The oligomeric complex formed by major histocompat-ibility complex (MHC) class II and chains and invariant chain (Ii) assembles in the endoplasmic retic-ulum and is then transported via the Golgi complex to compartments of the endocytic pathway. When Ii alone is expressed in CV1 cells it is sorted to endosomes. The Ii cytoplasmic tail has been found to be essential for tar-geting to these compartments. In order to characterize further the signals responsible for endosomal targeting, we have deleted various segments of the cytoplasmic tail. The Ii mutants were transiently expressed and the cel-lular location of the proteins was analyzed biochemi-cally and morphologically. The cytoplasmic tail of Ii was found to contain two endosomal targeting sequences within its cytoplasmic tail; one targeting sequence was present within amino acid residues 12-29 and deletion of this segment revealed the presence of a second endosomal targeting sequence, located within the first 11 amino acid residues. The presence of a leucine-isoleucine pair at positions 7 and 8 within this sequence was found to be essential for endosomal targeting. In addition, the presence of this L-I motif lead to accumulation of Ii molecules in large endosomal vacuoles containing lysosomal marker proteins. Both wild type Ii and Ii mutant molecules containing only one endosomal targeting sequence were rapidly internalized from the plasma membrane. When the Ii cytoplasmic tail was fused to the mem-brane-spanning region of neuraminidase, a resident plasma membrane protein, the resulting chimera (INA) was found in endocytic compartments containing lyso-somal marker proteins. Thus the cytoplasmic tail of Ii is sufficient for targeting to the endocytic/lysosomal pathway." @default.
• W4234285465 created "2022-05-12" @default.
• W4234285465 creator A5029719285 @default.
• W4234285465 creator A5030057121 @default.
• W4234285465 creator A5044213528 @default.
• W4234285465 date "1993-11-01" @default.
• W4234285465 modified "2023-10-09" @default.
• W4234285465 title "The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail" @default.
• W4234285465 cites W128647466 @default.
• W4234285465 cites W130273196 @default.
• W4234285465 cites W1525792717 @default.
• W4234285465 cites W1534629298 @default.
• W4234285465 cites W1570650398 @default.
• W4234285465 cites W1645373081 @default.
• W4234285465 cites W1801856853 @default.
• W4234285465 cites W1968774879 @default.
• W4234285465 cites W1969227168 @default.
• W4234285465 cites W1970654655 @default.
• W4234285465 cites W1974048907 @default.
• W4234285465 cites W1977834451 @default.
• W4234285465 cites W1979757599 @default.
• W4234285465 cites W1991039911 @default.
• W4234285465 cites W1992438598 @default.
• W4234285465 cites W1995482121 @default.
• W4234285465 cites W2004468088 @default.
• W4234285465 cites W2009399134 @default.
• W4234285465 cites W2017210232 @default.
• W4234285465 cites W2022697750 @default.
• W4234285465 cites W2024258680 @default.
• W4234285465 cites W2025661319 @default.
• W4234285465 cites W2027076158 @default.
• W4234285465 cites W2027978484 @default.
• W4234285465 cites W2030812496 @default.
• W4234285465 cites W2031117778 @default.
• W4234285465 cites W2035900036 @default.
• W4234285465 cites W2036136061 @default.
• W4234285465 cites W2036162866 @default.
• W4234285465 cites W2039115186 @default.
• W4234285465 cites W2042471874 @default.
• W4234285465 cites W2044343226 @default.
• W4234285465 cites W2047848139 @default.
• W4234285465 cites W2048481017 @default.
• W4234285465 cites W2049583570 @default.
• W4234285465 cites W2050960932 @default.
• W4234285465 cites W2052736790 @default.
• W4234285465 cites W2054385006 @default.
• W4234285465 cites W2059031237 @default.
• W4234285465 cites W2060215125 @default.
• W4234285465 cites W2066844508 @default.
• W4234285465 cites W2066873997 @default.
• W4234285465 cites W2067691363 @default.
• W4234285465 cites W2067761527 @default.
• W4234285465 cites W2069039144 @default.
• W4234285465 cites W2082091164 @default.
• W4234285465 cites W2088167128 @default.
• W4234285465 cites W2091686762 @default.
• W4234285465 cites W2095606352 @default.
• W4234285465 cites W2100075764 @default.
• W4234285465 cites W2100837269 @default.
• W4234285465 cites W2107312415 @default.
• W4234285465 cites W2118640836 @default.
• W4234285465 cites W2125841464 @default.
• W4234285465 cites W2128674875 @default.
• W4234285465 cites W2130452852 @default.
• W4234285465 cites W2138270253 @default.
• W4234285465 cites W2138466097 @default.
• W4234285465 cites W2150142144 @default.
• W4234285465 cites W2150207458 @default.
• W4234285465 cites W2152708819 @default.
• W4234285465 cites W2158614848 @default.
• W4234285465 cites W2168524203 @default.
• W4234285465 cites W2171821916 @default.
• W4234285465 cites W2340938366 @default.
• W4234285465 cites W2407094788 @default.
• W4234285465 cites W270749527 @default.
• W4234285465 cites W4256551677 @default.
• W4234285465 cites W99380436 @default.
• W4234285465 doi "https://doi.org/10.1242/jcs.106.3.831" @default.
• W4234285465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8308066" @default.
• W4234285465 hasPublicationYear "1993" @default.
• W4234285465 type Work @default.
• W4234285465 citedByCount "176" @default.
• W4234285465 countsByYear W42342854652012 @default.
• W4234285465 countsByYear W42342854652013 @default.
• W4234285465 countsByYear W42342854652014 @default.
• W4234285465 countsByYear W42342854652015 @default.
• W4234285465 countsByYear W42342854652016 @default.
• W4234285465 countsByYear W42342854652017 @default.
• W4234285465 countsByYear W42342854652018 @default.
• W4234285465 countsByYear W42342854652019 @default.
• W4234285465 countsByYear W42342854652020 @default.
• W4234285465 countsByYear W42342854652021 @default.
• W4234285465 countsByYear W42342854652023 @default.
• W4234285465 crossrefType "journal-article" @default.
• W4234285465 hasAuthorship W4234285465A5029719285 @default.
• W4234285465 hasAuthorship W4234285465A5030057121 @default.
• W4234285465 hasAuthorship W4234285465A5044213528 @default.
• W4234285465 hasBestOaLocation W42342854652 @default.

• next