FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234299023> ?p ?o ?g. }

• W4234299023 endingPage "1091" @default.
• W4234299023 startingPage "1083" @default.
• W4234299023 abstract "The murine alpha B-crystallin gene was cloned and its expression was examined. In the mouse, significant levels of alpha B-crystallin RNA were detected not only in lens but also in heart, skeletal muscle, kidney, and lung; low and trace levels were detected in brain and spleen, respectively. The RNA species in lung, brain, and spleen was 400 to 500 bases larger than that in the other tissues. Transcription in lens, heart, skeletal muscle, kidney, and brain initiated at the same position. A mouse alpha B-crystallin mini-gene was constructed and was introduced into the germ line of mice, and its expression was demonstrated to parallel that of the endogenous gene. Transgene RNA was always detected in lens, heart, and skeletal muscle, while expression in kidney and lung was variable; it remains uncertain whether there is transgene expression in brain and spleen. These results demonstrate that regulatory sequences controlling expression of the alpha B-crystallin gene lie between sequences 666 base pairs upstream of the transcription initiation site and 2.4 kilobase pairs downstream of the poly(A) addition site and are not located within the introns. Transfection studies with a series of alpha B-crystallin mini-gene deletion mutants revealed that sequences between positions -222 and -167 were required for efficient expression in primary embryonic chick lens cells; sequences downstream of the poly(A) addition signal were dispensable for expression in this in vitro system." @default.
• W4234299023 created "2022-05-12" @default.
• W4234299023 creator A5062647435 @default.
• W4234299023 creator A5065736037 @default.
• W4234299023 creator A5067297656 @default.
• W4234299023 date "1989-03-01" @default.
• W4234299023 modified "2023-10-18" @default.
• W4234299023 title "Expression of the murine alpha B-crystallin gene is not restricted to the lens" @default.
• W4234299023 cites W1516901270 @default.
• W4234299023 cites W1521953877 @default.
• W4234299023 cites W1560117034 @default.
• W4234299023 cites W1597541773 @default.
• W4234299023 cites W1950817823 @default.
• W4234299023 cites W1968283357 @default.
• W4234299023 cites W1975781544 @default.
• W4234299023 cites W1987054463 @default.
• W4234299023 cites W1987458920 @default.
• W4234299023 cites W1987713916 @default.
• W4234299023 cites W1991310329 @default.
• W4234299023 cites W1997675834 @default.
• W4234299023 cites W2002609010 @default.
• W4234299023 cites W2010356985 @default.
• W4234299023 cites W2022490019 @default.
• W4234299023 cites W2029447197 @default.
• W4234299023 cites W2030397711 @default.
• W4234299023 cites W2033065494 @default.
• W4234299023 cites W2033597620 @default.
• W4234299023 cites W2035919478 @default.
• W4234299023 cites W2043810469 @default.
• W4234299023 cites W2059605176 @default.
• W4234299023 cites W2060193542 @default.
• W4234299023 cites W2060333964 @default.
• W4234299023 cites W2063450941 @default.
• W4234299023 cites W2066013441 @default.
• W4234299023 cites W2071585046 @default.
• W4234299023 cites W2071962920 @default.
• W4234299023 cites W2072466974 @default.
• W4234299023 cites W2076521338 @default.
• W4234299023 cites W2078383532 @default.
• W4234299023 cites W2097295307 @default.
• W4234299023 cites W2135338236 @default.
• W4234299023 cites W2138270253 @default.
• W4234299023 cites W2141747651 @default.
• W4234299023 cites W2149804554 @default.
• W4234299023 cites W2149858671 @default.
• W4234299023 cites W2153258132 @default.
• W4234299023 cites W2157586076 @default.
• W4234299023 cites W2173218272 @default.
• W4234299023 cites W2259815142 @default.
• W4234299023 cites W4234667455 @default.
• W4234299023 cites W4241531133 @default.
• W4234299023 cites W4294216491 @default.
• W4234299023 doi "https://doi.org/10.1128/mcb.9.3.1083-1091.1989" @default.
• W4234299023 hasPublicationYear "1989" @default.
• W4234299023 type Work @default.
• W4234299023 citedByCount "5" @default.
• W4234299023 countsByYear W42342990232017 @default.
• W4234299023 countsByYear W42342990232022 @default.
• W4234299023 crossrefType "journal-article" @default.
• W4234299023 hasAuthorship W4234299023A5062647435 @default.
• W4234299023 hasAuthorship W4234299023A5065736037 @default.
• W4234299023 hasAuthorship W4234299023A5067297656 @default.
• W4234299023 hasConcept C102230213 @default.
• W4234299023 hasConcept C104317684 @default.
• W4234299023 hasConcept C105580179 @default.
• W4234299023 hasConcept C105702510 @default.
• W4234299023 hasConcept C138885662 @default.
• W4234299023 hasConcept C150194340 @default.
• W4234299023 hasConcept C153911025 @default.
• W4234299023 hasConcept C165864922 @default.
• W4234299023 hasConcept C179926584 @default.
• W4234299023 hasConcept C2779959927 @default.
• W4234299023 hasConcept C41895202 @default.
• W4234299023 hasConcept C54355233 @default.
• W4234299023 hasConcept C67705224 @default.
• W4234299023 hasConcept C7263354 @default.
• W4234299023 hasConcept C86803240 @default.
• W4234299023 hasConcept C94671646 @default.
• W4234299023 hasConceptScore W4234299023C102230213 @default.
• W4234299023 hasConceptScore W4234299023C104317684 @default.
• W4234299023 hasConceptScore W4234299023C105580179 @default.
• W4234299023 hasConceptScore W4234299023C105702510 @default.
• W4234299023 hasConceptScore W4234299023C138885662 @default.
• W4234299023 hasConceptScore W4234299023C150194340 @default.
• W4234299023 hasConceptScore W4234299023C153911025 @default.
• W4234299023 hasConceptScore W4234299023C165864922 @default.
• W4234299023 hasConceptScore W4234299023C179926584 @default.
• W4234299023 hasConceptScore W4234299023C2779959927 @default.
• W4234299023 hasConceptScore W4234299023C41895202 @default.
• W4234299023 hasConceptScore W4234299023C54355233 @default.
• W4234299023 hasConceptScore W4234299023C67705224 @default.
• W4234299023 hasConceptScore W4234299023C7263354 @default.
• W4234299023 hasConceptScore W4234299023C86803240 @default.
• W4234299023 hasConceptScore W4234299023C94671646 @default.
• W4234299023 hasIssue "3" @default.
• W4234299023 hasLocation W42342990231 @default.
• W4234299023 hasOpenAccess W4234299023 @default.
• W4234299023 hasPrimaryLocation W42342990231 @default.

• next