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- W4234438786 abstract "Abstract On-chip glycan biosynthesis is an effective strategy for preparing useful complex glycan sources and for preparing glycan-involved applications simultaneously. However, current methods have some limitations when analyzing biosynthesized glycans and optimizing enzymatic reactions, which could result in undefined glycan structures on a surface, leading to unequal and unreliable results. In this work, a novel glycan chip was developed by introducing a pH-responsive i-motif DNA linker to control the immobilization and isolation of glycans on chip surfaces in a pH-dependent manner. On-chip enzymatic glycosylations were optimized for uniform biosynthesis of cancer-associated Globo H hexasaccharide and its related complex glycans through stepwise quantitative analyses of isolated products from the surface. Successful interaction analyses of the anti-Globo H antibody and MCF-7 breast cancer cells with on-chip biosynthesized Globo H-related glycans demonstrated the feasibility of the structure-switchable DNA linker-based glycan chip platform for on-chip complex glycan biosynthesis and glycan-involved applications." @default.
- W4234438786 created "2022-05-12" @default.
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- W4234438786 date "2021-05-26" @default.
- W4234438786 modified "2023-09-27" @default.
- W4234438786 title "Glycan chip based on structure switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans" @default.
- W4234438786 doi "https://doi.org/10.21203/rs.3.pex-1350/v1" @default.
- W4234438786 hasPublicationYear "2021" @default.
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