FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234570744> ?p ?o ?g. }

• W4234570744 endingPage "792" @default.
• W4234570744 startingPage "787" @default.
• W4234570744 abstract "Abstract A common perception is that cancer risk reduction is passive, such as not smoking. However, advances in the understanding of cancer biology and in cancer treatment modalities suggest that it is now timely to consider anew cancer risk reduction by active, including pharmacologic, approaches. Risk avoidance approaches are certainly important, but other approaches are important as well, as exemplified by the irony that most new lung cancers occur in former smokers, or current avoiders. Cancer interception is the active way of combating cancer and carcinogenesis at earlier and earlier stages. A great challenge is to educate people that the development of cancers, like heart disease, typically takes years and accordingly can potentially be intercepted with risk-reducing agents in the same way that advanced cancers can be treated with drugs or that cardiovascular disease can be intercepted with antihypertensive and other risk-reducing drugs. The cancer biology behind cancer interception is increasingly solid. For example, hedgehog pathway studies of mutations in the patched homolog 1 (PTCH1) gene, which constitutively activates Smoothened (SMO), led to development of an oral SMO inhibitor active in advanced basal cell carcinoma and which, in very high-risk Gorlin syndrome patients (germ line PTCH1 mutation), is nearly completely clinically effective in intercepting basal cell neoplasia. Also, the oral immunomodulator lenalidomide, first found to be active in advanced, relapsed multiple myeloma, was highly effective in intercepting the precursor stage, high-risk smoldering multiple myeloma from progressing. These are but two exciting, recent examples of the many advances in cancer research that have created an optimal time to discover and implement cancer interception. The multifaceted roles of telomere maintenance in both fueling advanced cancers and, at early stages, keeping them at bay, also highlight how the growing knowledge of cancer biology opens avenues for cancer interception. Emerging molecular techniques, including next-generation sequencing platforms, that account for a large part of the remarkable recent advances in cancer biology are now being applied to interception of premalignancy. Keeping the medical community and public at large informed about possibilities for actively intercepting cancer will be important for gaining acceptance of this increasingly powerful approach to lessening the cancer burden. Cancer Prev Res; 4(6); 787–92. ©2011 AACR." @default.
• W4234570744 created "2022-05-12" @default.
• W4234570744 creator A5064437582 @default.
• W4234570744 date "2011-06-01" @default.
• W4234570744 modified "2023-10-13" @default.
• W4234570744 title "Cancer Interception" @default.
• W4234570744 cites W1965431780 @default.
• W4234570744 cites W1976051908 @default.
• W4234570744 cites W1976314340 @default.
• W4234570744 cites W1980665690 @default.
• W4234570744 cites W1985587689 @default.
• W4234570744 cites W1986129954 @default.
• W4234570744 cites W1986335721 @default.
• W4234570744 cites W1988783822 @default.
• W4234570744 cites W1995324996 @default.
• W4234570744 cites W2010417927 @default.
• W4234570744 cites W2012382065 @default.
• W4234570744 cites W2014896987 @default.
• W4234570744 cites W2021954218 @default.
• W4234570744 cites W2035720189 @default.
• W4234570744 cites W2047218894 @default.
• W4234570744 cites W2048786186 @default.
• W4234570744 cites W2055395862 @default.
• W4234570744 cites W2071661381 @default.
• W4234570744 cites W2075172158 @default.
• W4234570744 cites W2088457548 @default.
• W4234570744 cites W2097529540 @default.
• W4234570744 cites W2098085059 @default.
• W4234570744 cites W2102650042 @default.
• W4234570744 cites W2102937816 @default.
• W4234570744 cites W2103611039 @default.
• W4234570744 cites W2105393015 @default.
• W4234570744 cites W2109229110 @default.
• W4234570744 cites W2117692326 @default.
• W4234570744 cites W2120077385 @default.
• W4234570744 cites W2122506368 @default.
• W4234570744 cites W2127711365 @default.
• W4234570744 cites W2129041527 @default.
• W4234570744 cites W2137807247 @default.
• W4234570744 cites W2138418129 @default.
• W4234570744 cites W2139190739 @default.
• W4234570744 cites W2139470984 @default.
• W4234570744 cites W2144196452 @default.
• W4234570744 cites W2146233513 @default.
• W4234570744 cites W2149063601 @default.
• W4234570744 cites W2151036184 @default.
• W4234570744 cites W2154643978 @default.
• W4234570744 cites W2155530804 @default.
• W4234570744 cites W2160076878 @default.
• W4234570744 cites W2161102475 @default.
• W4234570744 cites W2161948433 @default.
• W4234570744 cites W2167064353 @default.
• W4234570744 cites W2169449395 @default.
• W4234570744 cites W2171972386 @default.
• W4234570744 cites W2323972478 @default.
• W4234570744 cites W2566863750 @default.
• W4234570744 cites W3135529189 @default.
• W4234570744 cites W4254675170 @default.
• W4234570744 cites W4362207783 @default.
• W4234570744 doi "https://doi.org/10.1158/1940-6207.capr-11-0195" @default.
• W4234570744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21636545" @default.
• W4234570744 hasPublicationYear "2011" @default.
• W4234570744 type Work @default.
• W4234570744 citedByCount "74" @default.
• W4234570744 countsByYear W42345707442012 @default.
• W4234570744 countsByYear W42345707442013 @default.
• W4234570744 countsByYear W42345707442014 @default.
• W4234570744 countsByYear W42345707442015 @default.
• W4234570744 countsByYear W42345707442016 @default.
• W4234570744 countsByYear W42345707442017 @default.
• W4234570744 countsByYear W42345707442018 @default.
• W4234570744 countsByYear W42345707442019 @default.
• W4234570744 countsByYear W42345707442020 @default.
• W4234570744 countsByYear W42345707442021 @default.
• W4234570744 countsByYear W42345707442022 @default.
• W4234570744 countsByYear W42345707442023 @default.
• W4234570744 crossrefType "journal-article" @default.
• W4234570744 hasAuthorship W4234570744A5064437582 @default.
• W4234570744 hasConcept C104317684 @default.
• W4234570744 hasConcept C121608353 @default.
• W4234570744 hasConcept C126322002 @default.
• W4234570744 hasConcept C143998085 @default.
• W4234570744 hasConcept C145837895 @default.
• W4234570744 hasConcept C2778539099 @default.
• W4234570744 hasConcept C2778804307 @default.
• W4234570744 hasConcept C2779477247 @default.
• W4234570744 hasConcept C2780234812 @default.
• W4234570744 hasConcept C3019992690 @default.
• W4234570744 hasConcept C502942594 @default.
• W4234570744 hasConcept C54355233 @default.
• W4234570744 hasConcept C60644358 @default.
• W4234570744 hasConcept C71924100 @default.
• W4234570744 hasConcept C86803240 @default.
• W4234570744 hasConceptScore W4234570744C104317684 @default.
• W4234570744 hasConceptScore W4234570744C121608353 @default.
• W4234570744 hasConceptScore W4234570744C126322002 @default.
• W4234570744 hasConceptScore W4234570744C143998085 @default.
• W4234570744 hasConceptScore W4234570744C145837895 @default.

• next