FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234587772> ?p ?o ?g. }

• W4234587772 abstract "Small extracellular vesicles (EVs) present fairly distinctive lipid membrane features in the extracellular environment. These include high curvature, lipid packing defects and a relative abundance in lipids such as phosphatidylserine and ceramide. EVs membrane could be then considered as a universal marker, alternative or complementary to traditional characteristic surface-associated proteins. Here we introduce the use of membrane sensing peptides as new, highly efficient ligands for EVs capturing onto bioanalytical chips to directly integrate EVs capturing and analysis on a microarray platform, even using serum without pre-isolation steps. EVs were analyzed by label-free, single particle counting and by fluorescence co-localization immune-staining with labelled anti-CD9/anti-CD63/anti-CD81 antibodies. Peptides performed as selective yet general EVs baits and showed a binding capacity higher than anti-tetraspanins antibodies. Insights into surface chemistry for optimal peptide performance are also discussed, as capturing efficiency is strictly bound to probes surface orientation and multivalency effects. We anticipate that this new class of ligands, also due to the versatility and limited costs of synthetic peptides, may greatly enrich the molecular toolbox for EVs analysis." @default.
• W4234587772 created "2022-05-12" @default.
• W4234587772 creator A5001443039 @default.
• W4234587772 creator A5006718601 @default.
• W4234587772 creator A5011971881 @default.
• W4234587772 creator A5018179173 @default.
• W4234587772 creator A5027847501 @default.
• W4234587772 creator A5029006962 @default.
• W4234587772 creator A5033126156 @default.
• W4234587772 creator A5034735571 @default.
• W4234587772 creator A5041692278 @default.
• W4234587772 creator A5047568509 @default.
• W4234587772 creator A5049111512 @default.
• W4234587772 creator A5058902689 @default.
• W4234587772 creator A5061616796 @default.
• W4234587772 creator A5086763607 @default.
• W4234587772 date "2020-03-02" @default.
• W4234587772 modified "2023-10-08" @default.
• W4234587772 title "Membrane-Binding Peptides for Extracellular Vesicles On-Chip Analysis" @default.
• W4234587772 doi "https://doi.org/10.26434/chemrxiv.9885167.v3" @default.
• W4234587772 hasPublicationYear "2020" @default.
• W4234587772 type Work @default.
• W4234587772 citedByCount "1" @default.
• W4234587772 countsByYear W42345877722020 @default.
• W4234587772 crossrefType "posted-content" @default.
• W4234587772 hasAuthorship W4234587772A5001443039 @default.
• W4234587772 hasAuthorship W4234587772A5006718601 @default.
• W4234587772 hasAuthorship W4234587772A5011971881 @default.
• W4234587772 hasAuthorship W4234587772A5018179173 @default.
• W4234587772 hasAuthorship W4234587772A5027847501 @default.
• W4234587772 hasAuthorship W4234587772A5029006962 @default.
• W4234587772 hasAuthorship W4234587772A5033126156 @default.
• W4234587772 hasAuthorship W4234587772A5034735571 @default.
• W4234587772 hasAuthorship W4234587772A5041692278 @default.
• W4234587772 hasAuthorship W4234587772A5047568509 @default.
• W4234587772 hasAuthorship W4234587772A5049111512 @default.
• W4234587772 hasAuthorship W4234587772A5058902689 @default.
• W4234587772 hasAuthorship W4234587772A5061616796 @default.
• W4234587772 hasAuthorship W4234587772A5086763607 @default.
• W4234587772 hasBestOaLocation W42345877721 @default.
• W4234587772 hasConcept C104317684 @default.
• W4234587772 hasConcept C12554922 @default.
• W4234587772 hasConcept C130316041 @default.
• W4234587772 hasConcept C145059251 @default.
• W4234587772 hasConcept C1491633281 @default.
• W4234587772 hasConcept C159047783 @default.
• W4234587772 hasConcept C171250308 @default.
• W4234587772 hasConcept C185592680 @default.
• W4234587772 hasConcept C190283241 @default.
• W4234587772 hasConcept C192562407 @default.
• W4234587772 hasConcept C20518536 @default.
• W4234587772 hasConcept C2522874641 @default.
• W4234587772 hasConcept C2776408679 @default.
• W4234587772 hasConcept C2776507628 @default.
• W4234587772 hasConcept C2777208748 @default.
• W4234587772 hasConcept C2777851122 @default.
• W4234587772 hasConcept C2779281246 @default.
• W4234587772 hasConcept C2908689518 @default.
• W4234587772 hasConcept C2992929900 @default.
• W4234587772 hasConcept C41625074 @default.
• W4234587772 hasConcept C55493867 @default.
• W4234587772 hasConcept C86803240 @default.
• W4234587772 hasConcept C95444343 @default.
• W4234587772 hasConceptScore W4234587772C104317684 @default.
• W4234587772 hasConceptScore W4234587772C12554922 @default.
• W4234587772 hasConceptScore W4234587772C130316041 @default.
• W4234587772 hasConceptScore W4234587772C145059251 @default.
• W4234587772 hasConceptScore W4234587772C1491633281 @default.
• W4234587772 hasConceptScore W4234587772C159047783 @default.
• W4234587772 hasConceptScore W4234587772C171250308 @default.
• W4234587772 hasConceptScore W4234587772C185592680 @default.
• W4234587772 hasConceptScore W4234587772C190283241 @default.
• W4234587772 hasConceptScore W4234587772C192562407 @default.
• W4234587772 hasConceptScore W4234587772C20518536 @default.
• W4234587772 hasConceptScore W4234587772C2522874641 @default.
• W4234587772 hasConceptScore W4234587772C2776408679 @default.
• W4234587772 hasConceptScore W4234587772C2776507628 @default.
• W4234587772 hasConceptScore W4234587772C2777208748 @default.
• W4234587772 hasConceptScore W4234587772C2777851122 @default.
• W4234587772 hasConceptScore W4234587772C2779281246 @default.
• W4234587772 hasConceptScore W4234587772C2908689518 @default.
• W4234587772 hasConceptScore W4234587772C2992929900 @default.
• W4234587772 hasConceptScore W4234587772C41625074 @default.
• W4234587772 hasConceptScore W4234587772C55493867 @default.
• W4234587772 hasConceptScore W4234587772C86803240 @default.
• W4234587772 hasConceptScore W4234587772C95444343 @default.
• W4234587772 hasLocation W42345877721 @default.
• W4234587772 hasOpenAccess W4234587772 @default.
• W4234587772 hasPrimaryLocation W42345877721 @default.
• W4234587772 hasRelatedWork W16780001 @default.
• W4234587772 hasRelatedWork W17431464 @default.
• W4234587772 hasRelatedWork W18077933 @default.
• W4234587772 hasRelatedWork W22476893 @default.
• W4234587772 hasRelatedWork W22781674 @default.
• W4234587772 hasRelatedWork W23244024 @default.
• W4234587772 hasRelatedWork W27250302 @default.
• W4234587772 hasRelatedWork W4677771 @default.
• W4234587772 hasRelatedWork W7946810 @default.
• W4234587772 hasRelatedWork W29301030 @default.
• W4234587772 isParatext "false" @default.

• next