Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234620201> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4234620201 endingPage "2127" @default.
- W4234620201 startingPage "2120" @default.
- W4234620201 abstract "A clone containing the entire goat epsilon V beta-globin gene, which lies downstream from the two tandemly duplicated four-gene sets containing the beta C and beta A genes in the linkage group 5'-epsilon I-epsilon II-psi beta X-beta C-epsilon III-epsilon IV-psi beta Z-beta A-epsilon V-3', was isolated, and the sequence of the gene was determined. epsilon V is most homologous to the first gene in each of these sets, epsilon I and epsilon III, and appears to be a third duplicated copy of these genes, possibly the first gene in a third four-gene set. Homology of epsilon V to epsilon I is very high (93.2%) in coding regions, and all transcription, processing, and potential translation consensus sequence elements appear to be present, although the Hogness box of epsilon V is altered compared with that of epsilon I by the deletion of an A(AATAAAA----AATAAA). Nevertheless, epsilon V is clearly a pseudogene as a result of two deletions and one insertion (or insertion-deletion) in its coding sequence, the first of which produces an in-frame stop codon at amino acid 54. Unlike the more highly mutated goat beta-like pseudogene duplicates psi beta X and psi beta Z, epsilon V acquired its defects after the duplication event in which it was created. Its recently acquired defects have left the epsilon V promoter sufficiently conserved to retain transcriptional activity in vitro. The acquisition of defects by this gene may be related to the multiple gene duplications which have created at least five epsilon type genes in the goat beta-globin locus." @default.
- W4234620201 created "2022-05-12" @default.
- W4234620201 creator A5002369147 @default.
- W4234620201 creator A5007355621 @default.
- W4234620201 date "1984-10-01" @default.
- W4234620201 modified "2023-10-14" @default.
- W4234620201 title "Identification of a recently evolved goat embryonic beta-globin pseudogene which retains transcriptional activity in vitro." @default.
- W4234620201 doi "https://doi.org/10.1128/mcb.4.10.2120" @default.
- W4234620201 hasPublicationYear "1984" @default.
- W4234620201 type Work @default.
- W4234620201 citedByCount "9" @default.
- W4234620201 crossrefType "journal-article" @default.
- W4234620201 hasAuthorship W4234620201A5002369147 @default.
- W4234620201 hasAuthorship W4234620201A5007355621 @default.
- W4234620201 hasBestOaLocation W42346202012 @default.
- W4234620201 hasConcept C104317684 @default.
- W4234620201 hasConcept C141231307 @default.
- W4234620201 hasConcept C153911025 @default.
- W4234620201 hasConcept C165525559 @default.
- W4234620201 hasConcept C199360897 @default.
- W4234620201 hasConcept C20580545 @default.
- W4234620201 hasConcept C2776174256 @default.
- W4234620201 hasConcept C34957205 @default.
- W4234620201 hasConcept C41008148 @default.
- W4234620201 hasConcept C54355233 @default.
- W4234620201 hasConcept C86803240 @default.
- W4234620201 hasConcept C91779695 @default.
- W4234620201 hasConceptScore W4234620201C104317684 @default.
- W4234620201 hasConceptScore W4234620201C141231307 @default.
- W4234620201 hasConceptScore W4234620201C153911025 @default.
- W4234620201 hasConceptScore W4234620201C165525559 @default.
- W4234620201 hasConceptScore W4234620201C199360897 @default.
- W4234620201 hasConceptScore W4234620201C20580545 @default.
- W4234620201 hasConceptScore W4234620201C2776174256 @default.
- W4234620201 hasConceptScore W4234620201C34957205 @default.
- W4234620201 hasConceptScore W4234620201C41008148 @default.
- W4234620201 hasConceptScore W4234620201C54355233 @default.
- W4234620201 hasConceptScore W4234620201C86803240 @default.
- W4234620201 hasConceptScore W4234620201C91779695 @default.
- W4234620201 hasIssue "10" @default.
- W4234620201 hasLocation W42346202011 @default.
- W4234620201 hasLocation W42346202012 @default.
- W4234620201 hasLocation W42346202013 @default.
- W4234620201 hasOpenAccess W4234620201 @default.
- W4234620201 hasPrimaryLocation W42346202011 @default.
- W4234620201 hasRelatedWork W1884183593 @default.
- W4234620201 hasRelatedWork W1964274011 @default.
- W4234620201 hasRelatedWork W1967082212 @default.
- W4234620201 hasRelatedWork W1999325162 @default.
- W4234620201 hasRelatedWork W2004096242 @default.
- W4234620201 hasRelatedWork W2029633625 @default.
- W4234620201 hasRelatedWork W2055100847 @default.
- W4234620201 hasRelatedWork W221933387 @default.
- W4234620201 hasRelatedWork W2388546544 @default.
- W4234620201 hasRelatedWork W4256612147 @default.
- W4234620201 hasVolume "4" @default.
- W4234620201 isParatext "false" @default.
- W4234620201 isRetracted "false" @default.
- W4234620201 workType "article" @default.