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- W4234629586 abstract "The case for cancer prevention and screening in oesophageal cancer is based on the global burden and natural history of the disease. This chapter focuses on adenocarcinoma (EAC) as a worked example of the opportunities and controversies in cancer prevention and screening. EAC is predominantly a disease of middle age. EAC is more common in men. The association between gastro-oesophageal reflux disease, hiatus hernia, and EAC has long been established. Obesity is also independently associated with a higher risk of EAC via mechanisms that probably involve pro-inflammatory and immune modulation. Smoking, alcohol consumption, and poor diet have all been associated with a higher risk of EAC. Oesophageal cancer represents a significant challenge for prevention and screening. In the case of adenocarcinoma in Western populations, persistent heartburn is the only recognized symptom for early disease." @default.
- W4234629586 created "2022-05-12" @default.
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- W4234629586 date "2018-08-14" @default.
- W4234629586 modified "2023-09-26" @default.
- W4234629586 title "Oesophageal cancer" @default.
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- W4234629586 doi "https://doi.org/10.1002/9781118990957.ch21" @default.
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