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- W4234694583 abstract "Membrane fusion is essential for eukaryotic cell biology, embryogenesis, the formation of many organs, and infection of cells by enveloped viruses. However, lipid membranes do not merge spontaneously, mandating the activity of fusion protein complexes to achieve lipid merger. Cellular fusogens must be present on both donor and acceptor membrane, and protein components are recycled in an adenosine triphosphate-dependent step. By contrast, fusogenic viral glycoproteins harbor fusion peptides or loops in addition to transmembrane domains to simultaneously engage both membranes, and refolding in thermodynamically stable postfusion conformations is ultimately irreversible. Despite these differences, many basic structural and mechanistic principles governing membrane fusion are highly conserved among all fusion protein types analyzed. This article summarizes structural principles of different cellular and viral fusion proteins, outlines central steps of the fusion process, and discusses current methods to study cellular and viral membrane fusion." @default.
- W4234694583 created "2022-05-12" @default.
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- W4234694583 date "2013-01-01" @default.
- W4234694583 modified "2023-09-25" @default.
- W4234694583 title "Membrane Fusion" @default.
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- W4234694583 doi "https://doi.org/10.1016/b978-0-12-378630-2.00639-3" @default.
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