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- W4234698507 abstract "Abstract Background . An Italian project aims to review the scientific literature on the possible carcinogenicity of radiofrequency (100 kHz – 300 GHz) electromagnetic field (RF-EMF) exposure. The ENEA team has to carry out a systematic review of the in vivo studies on this topic. Objectives : Development of a protocol for a systematic review (meta-analysis included) to investigate the potential carcinogenic risk following RF-EMF in vivo exposure to doses above or within legal limits. The aim of this review is - to provide a descriptive and, if possible, a quantitative summaries of the results of the examined RF-EMF in vivo studies, together with an assessment of the consistency of observations and of the causes of heterogeneity. - to assess the weight of evidence to support or refute the hypothesis of carcinogenic effects caused by RF-EMF exposure and to draw conclusions about the potential for carcinogenicity of RF-EMF exposure. Methods: We will search for relevant studies in electronic academic databases and in the reference list of selected papers and reviews on the topic, including the descriptive reviews on RF-EMF carcinogenic effect carried out by international panels of experts since 2011. PECO’s statements were defined : experimental studies on rodents of both sexes, all ages and species, all genetic background (Population) exposed to RF-EMF alone, or in combination with other physical or chemical agents (Exposure); only studies reporting outcome data in exposed and sham control groups (Comparison);all types of cancer with all tumor-related outcome measures (Outcome) will be included.Only peer-reviewed articles written in English will be considered without limit in publication date.Eligibility criteria were defined for screening of papers, moreover the risk of bias assessment will be performed using a specific risk of bias tool for animal studies. Only studies with definitely low and/or probably low risk of bias will be included in the analysis. A meta-analysis will be performed, if feasible, for all outcome measures: for subgroup analysis a minimum of 3 studies per subgroup will be required. If meta-analysis will not be possible, data will be reported through the descriptive summary. Systematic review registration : PROSPERO CRD42020191105." @default.
- W4234698507 created "2022-05-12" @default.
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- W4234698507 date "2020-12-08" @default.
- W4234698507 modified "2023-10-16" @default.
- W4234698507 title "Protocol for a Systematic Review of the in vivo Studies on Radiofrequency (100 kHz – 300 GHz) Electromagnetic Field Exposure and Cancer" @default.
- W4234698507 doi "https://doi.org/10.21203/rs.3.rs-121891/v1" @default.
- W4234698507 hasPublicationYear "2020" @default.
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