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• W4234709818 abstract "Background The mammalian placenta plays central roles in maternal tolerance of the semi-allogeneic fetus (immune function) and fluid balance between the maternal and fetal compartments. The aim of this study was to describe the distribution of lymphatic vessels in human decidua. Methods Placental bed, and non-placental bed biopsies were obtained from 46 women: 41 undergoing elective termination of pregnancy at 6-18 weeks and 5 women undergoing elective caesarean section at term. The H&E staining and double immunohistochemical labelling was performed on serial 3 μm sections to identify lymphatics in conjunction with either blood vessels, smooth muscle, epithelial and trophoblast cells. Representative photomicrographs were obtained. Descriptive findings of the organisation of lymphatics in human placental bed and decidua were made from 1638 images. Results Lymphatic vessels positive for podoplanin were abundant in hypersecretory endometrium at all stages of gestation. The decidua was nearly always devoid of lymphatics. There were structures that appeared to be regressing lymphatics. Lymphatic vessels were absent from the vicinity of spiral arteries surrounded by decidualised stromal cells and appeared larger and more elongated as gestation progressed. Proliferating lymphatic endothelial cells were identified in large vessels and in streaks. Conclusions We have made novel observations on lymphatics in the placental bed and their relationship with other structures throughout pregnancy. Endometrial stromal cell decidualisation results in a loss of lymphatics, with this phenomenon being particularly apparent around the spiral arteries. The mammalian placenta plays central roles in maternal tolerance of the semi-allogeneic fetus (immune function) and fluid balance between the maternal and fetal compartments. The aim of this study was to describe the distribution of lymphatic vessels in human decidua. Placental bed, and non-placental bed biopsies were obtained from 46 women: 41 undergoing elective termination of pregnancy at 6-18 weeks and 5 women undergoing elective caesarean section at term. The H&E staining and double immunohistochemical labelling was performed on serial 3 μm sections to identify lymphatics in conjunction with either blood vessels, smooth muscle, epithelial and trophoblast cells. Representative photomicrographs were obtained. Descriptive findings of the organisation of lymphatics in human placental bed and decidua were made from 1638 images. Lymphatic vessels positive for podoplanin were abundant in hypersecretory endometrium at all stages of gestation. The decidua was nearly always devoid of lymphatics. There were structures that appeared to be regressing lymphatics. Lymphatic vessels were absent from the vicinity of spiral arteries surrounded by decidualised stromal cells and appeared larger and more elongated as gestation progressed. Proliferating lymphatic endothelial cells were identified in large vessels and in streaks. We have made novel observations on lymphatics in the placental bed and their relationship with other structures throughout pregnancy. Endometrial stromal cell decidualisation results in a loss of lymphatics, with this phenomenon being particularly apparent around the spiral arteries." @default.
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• W4234709818 date "2011-01-01" @default.
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• W4234709818 title "Lymphatics in the human endometrium disappear during decidualisation" @default.
• W4234709818 doi "https://doi.org/10.1016/s0031-3025(16)33203-2" @default.
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