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- W4234715062 abstract "Abstract Background There is increasing concern regarding cardiovascular risk in individuals with non-alcoholic fatty liver disease. This study was conducted to evaluate whether hepatic steatosis with or without fibrosis is associated with progression of carotid atherosclerosis in patients with type 2 diabetes. Methods From a longitudinal cohort, we enrolled 1,120 type 2 diabetes patients who underwent repeated carotid artery ultrasonography every 1–2 years. Ultrasonographic findings at baseline and after 6–8 years were compared. Presence of hepatic steatosis was mainly assessed by abdominal ultrasonography; patients with hepatic steatosis were further evaluated for hepatic fibrosis according to fibrosis-4 index. We investigated the association between liver status and atherosclerosis progression. Results Of 1,120 patients, 636 (56.8%) were classified as having hepatic steatosis at baseline. After 6–8 years, 431 (38.5%) showed atherosclerosis progression. Hepatic steatosis was significantly associated with atherosclerosis progression (adjusted odds ratio[AOR]: 1.370, 95% CI: 1.025–1.832; p < 0.05). Among patients with hepatic steatosis, only individuals with fibrosis showed significant association with atherosclerosis progression (AOR: 1.636, 95% CI: 1.024–2.612; p < 0.05). Furthermore, subjects with hepatic steatosis & fibrosis and ≥ 4 components of metabolic syndrome criteria showed markedly increased risk of atherosclerosis progression (AOR: 2.776, 95% CI: 1.276–6.039; p < 0.05). The association between hepatic fibrosis and atherosclerosis progression was significant in all metabolic subgroups, regardless of age, body mass index, presence of metabolic syndrome, or insulin sensitivity (all p < 0.05). Conclusions Hepatic steatosis with fibrosis is independently associated with progression of carotid atherosclerosis in patients with type 2 diabetes." @default.
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- W4234715062 date "2020-04-27" @default.
- W4234715062 modified "2023-09-24" @default.
- W4234715062 title "Non-alcoholic steatohepatitis and progression of carotid atherosclerosis in patients with type 2 diabetes: a Korean cohort study" @default.
- W4234715062 doi "https://doi.org/10.21203/rs.3.rs-23583/v1" @default.
- W4234715062 hasPublicationYear "2020" @default.
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