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- W4234732490 abstract "<b>Objective: </b>To determine the respective associations of premorbid glucagon-like peptide-1 receptor agonists (GLP1-RA) and sodium-glucose-linked cotransporter 2 inhibitors (SGLT2i) use, compared to premorbid dipeptidyl peptidase-4 inhibitor (DPP4i) use, with severity of outcomes in the setting of COVID-19 infection. <p><b>Research Design and Methods: </b>We analyzed observational data from SARS-CoV-2-positive adults in the National COVID Cohort Collaborative, a multicenter, longitudinal U.S. cohort (January 2018–February 2021) with a prescription for GLP1-RA, SGLT2i, or DPP4i within 24 months of positive SARS-CoV-2 PCR test<b>. </b>The primary outcome was 60-day mortality, measured from positive SARS-CoV-2 test date. Secondary outcomes were total mortality during the observation period, and emergency room visits, hospitalization, and mechanical ventilation within 14 days. <b> </b>Associations were quantified with odds ratios (OR) estimated with targeted maximum likelihood estimation using a super learner approach, accounting for baseline characteristics. </p> <p><b>Results</b>: The study included 12,446 individuals (53.4% female, 62.5% White, mean±SD age 58.6±13.1 years). The 60-day mortality was 3.11% (387/12,446), with 2.06% (138/6,692) for GLP1-RA use, 2.32% (85/3,665) for SGLT2i use, and 5.67% (199/3,511) for DPP4i use. Both GLP1-RA and SGLT2i use was associated with lower 60-day mortality compared to DPP4i use (OR (95% confidence intervals (95%CI)): 0.54 (0.37–0.80) and 0.66 (0.50–0.86), respectively). Use of both medications was also associated with decreased total mortality, emergency room visits, and hospitalizations. </p> <b>Conclusions: </b>Among SARS-CoV-2-positive adults, premorbid GLP1-RA and SGLT2i use, compared to DPP4i use, was associated with lower odds of mortality and other adverse outcomes, although DPP4i users were older and generally sicker." @default.
- W4234732490 created "2022-05-12" @default.
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- W4234732490 date "2021-06-25" @default.
- W4234732490 modified "2023-10-13" @default.
- W4234732490 title "Association Between Glucagon-Like Peptide 1 Receptor Agonist and Sodium–Glucose Cotransporter 2 Inhibitor Use and COVID-19 Outcomes" @default.
- W4234732490 doi "https://doi.org/10.2337/figshare.14485170" @default.
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