Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234736270> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4234736270 endingPage "S788" @default.
- W4234736270 startingPage "S782" @default.
- W4234736270 abstract ": Glioma Stem Cells (GSCs) biology is finely regulated by a cross-talk of epigenetic mechanisms of regulation and the action of Oct4/Sox2 stemness gene drivers. Recently, a novel mechanism of regulation of miRNA-296-5p/Sox2 axis together with a new gene target (HMGA1) was described. The results raised questions of great relevance in glioma therapy, especially for the failure of the current radio/chemo-therapies. Can miR-296-5p/HMGA1/Sox2 axis trigger the differentiation of GSCs subpopulation? Can these findings be used in a short term to develop novel therapeutics to fight glioma? We thus believe that targeting HMGA1 in GSCs, via nano-liposomes miRNA delivery together with epigenetic drugs, could overcome the failure of the current therapies. Additionally, in silico analyses to identify other gene targets of miR-296-5p with data available in literature, found a remarkable association with new gene targets whose functions are related to cell differentiation processes. Taken altogether these findings make miR-296-5p an attractive target for human brain cancer treatment." @default.
- W4234736270 created "2022-05-12" @default.
- W4234736270 creator A5005241979 @default.
- W4234736270 creator A5013759067 @default.
- W4234736270 date "2016-10-01" @default.
- W4234736270 modified "2023-10-05" @default.
- W4234736270 title "Glioblastoma stem cells differentiation through epigenetic modulation is driven by miR-296-5p/HMGA1/Sox2 axis" @default.
- W4234736270 doi "https://doi.org/10.21037/tcr.2016.10.88" @default.
- W4234736270 hasPublicationYear "2016" @default.
- W4234736270 type Work @default.
- W4234736270 citedByCount "1" @default.
- W4234736270 countsByYear W42347362702023 @default.
- W4234736270 crossrefType "journal-article" @default.
- W4234736270 hasAuthorship W4234736270A5005241979 @default.
- W4234736270 hasAuthorship W4234736270A5013759067 @default.
- W4234736270 hasConcept C104317684 @default.
- W4234736270 hasConcept C145059251 @default.
- W4234736270 hasConcept C145103041 @default.
- W4234736270 hasConcept C1491633281 @default.
- W4234736270 hasConcept C169760540 @default.
- W4234736270 hasConcept C2777933648 @default.
- W4234736270 hasConcept C2778227246 @default.
- W4234736270 hasConcept C2780932548 @default.
- W4234736270 hasConcept C28328180 @default.
- W4234736270 hasConcept C41091548 @default.
- W4234736270 hasConcept C502942594 @default.
- W4234736270 hasConcept C54355233 @default.
- W4234736270 hasConcept C55427017 @default.
- W4234736270 hasConcept C70721500 @default.
- W4234736270 hasConcept C86803240 @default.
- W4234736270 hasConcept C95444343 @default.
- W4234736270 hasConceptScore W4234736270C104317684 @default.
- W4234736270 hasConceptScore W4234736270C145059251 @default.
- W4234736270 hasConceptScore W4234736270C145103041 @default.
- W4234736270 hasConceptScore W4234736270C1491633281 @default.
- W4234736270 hasConceptScore W4234736270C169760540 @default.
- W4234736270 hasConceptScore W4234736270C2777933648 @default.
- W4234736270 hasConceptScore W4234736270C2778227246 @default.
- W4234736270 hasConceptScore W4234736270C2780932548 @default.
- W4234736270 hasConceptScore W4234736270C28328180 @default.
- W4234736270 hasConceptScore W4234736270C41091548 @default.
- W4234736270 hasConceptScore W4234736270C502942594 @default.
- W4234736270 hasConceptScore W4234736270C54355233 @default.
- W4234736270 hasConceptScore W4234736270C55427017 @default.
- W4234736270 hasConceptScore W4234736270C70721500 @default.
- W4234736270 hasConceptScore W4234736270C86803240 @default.
- W4234736270 hasConceptScore W4234736270C95444343 @default.
- W4234736270 hasIssue "S4" @default.
- W4234736270 hasLocation W42347362701 @default.
- W4234736270 hasOpenAccess W4234736270 @default.
- W4234736270 hasPrimaryLocation W42347362701 @default.
- W4234736270 hasRelatedWork W1999902129 @default.
- W4234736270 hasRelatedWork W2015925550 @default.
- W4234736270 hasRelatedWork W2346533061 @default.
- W4234736270 hasRelatedWork W2520492110 @default.
- W4234736270 hasRelatedWork W2736734128 @default.
- W4234736270 hasRelatedWork W2758746412 @default.
- W4234736270 hasRelatedWork W2890284775 @default.
- W4234736270 hasRelatedWork W3007987940 @default.
- W4234736270 hasRelatedWork W3008610168 @default.
- W4234736270 hasRelatedWork W3211764250 @default.
- W4234736270 hasVolume "5" @default.
- W4234736270 isParatext "false" @default.
- W4234736270 isRetracted "false" @default.
- W4234736270 workType "article" @default.