Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234755708> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4234755708 endingPage "1831" @default.
- W4234755708 startingPage "1825" @default.
- W4234755708 abstract "Abstract We have developed a restriction map of the chromosome 21 breakpoint region involved in t(8;21)(q22;q22.3) acute myelogenous leukemia (AML) and have isolated a genomic junction clone containing chromosome 8 and 21 material. Using probes from these regions, rearrangements have been identified in each of nine cases of t(8;21) AML examined. In addition, we have isolated cDNA clones from a t(8;21) AML cDNA library that contain fused sequences from chromosome 8 and 21. The chromosome 8 component, referred to as ETO (for eight twenty-one), is encoded over a large genomic region, as suggested by the analysis of corresponding yeast artificial chromosomes (YACs). The DNA sequence of the chromosome 21 portion of the fusion transcript is derived from the normal AML1 gene. A striking similarity (67% identity over 387 bp, with a corresponding 69% amino acid identity) was detected between AML1 and the Drosophila segmentation gene, runt. The critical consequence of the translocation is the juxtaposition of 5′ sequences of AML1 to 3′ sequences of ETO, oriented telomere to centromere on the der(8) chromosome." @default.
- W4234755708 created "2022-05-12" @default.
- W4234755708 creator A5004347976 @default.
- W4234755708 creator A5012790675 @default.
- W4234755708 creator A5022113125 @default.
- W4234755708 creator A5026821827 @default.
- W4234755708 creator A5027850229 @default.
- W4234755708 creator A5049391728 @default.
- W4234755708 creator A5055386220 @default.
- W4234755708 creator A5085769284 @default.
- W4234755708 creator A5087213703 @default.
- W4234755708 creator A5087845534 @default.
- W4234755708 date "1992-10-01" @default.
- W4234755708 modified "2023-10-10" @default.
- W4234755708 title "Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt" @default.
- W4234755708 doi "https://doi.org/10.1182/blood.v80.7.1825.1825" @default.
- W4234755708 hasPublicationYear "1992" @default.
- W4234755708 type Work @default.
- W4234755708 citedByCount "437" @default.
- W4234755708 countsByYear W42347557082012 @default.
- W4234755708 countsByYear W42347557082013 @default.
- W4234755708 countsByYear W42347557082014 @default.
- W4234755708 countsByYear W42347557082015 @default.
- W4234755708 countsByYear W42347557082016 @default.
- W4234755708 countsByYear W42347557082017 @default.
- W4234755708 countsByYear W42347557082018 @default.
- W4234755708 countsByYear W42347557082019 @default.
- W4234755708 countsByYear W42347557082020 @default.
- W4234755708 countsByYear W42347557082021 @default.
- W4234755708 countsByYear W42347557082022 @default.
- W4234755708 countsByYear W42347557082023 @default.
- W4234755708 crossrefType "journal-article" @default.
- W4234755708 hasAuthorship W4234755708A5004347976 @default.
- W4234755708 hasAuthorship W4234755708A5012790675 @default.
- W4234755708 hasAuthorship W4234755708A5022113125 @default.
- W4234755708 hasAuthorship W4234755708A5026821827 @default.
- W4234755708 hasAuthorship W4234755708A5027850229 @default.
- W4234755708 hasAuthorship W4234755708A5049391728 @default.
- W4234755708 hasAuthorship W4234755708A5055386220 @default.
- W4234755708 hasAuthorship W4234755708A5085769284 @default.
- W4234755708 hasAuthorship W4234755708A5087213703 @default.
- W4234755708 hasAuthorship W4234755708A5087845534 @default.
- W4234755708 hasBestOaLocation W42347557081 @default.
- W4234755708 hasConcept C104317684 @default.
- W4234755708 hasConcept C122735190 @default.
- W4234755708 hasConcept C130693829 @default.
- W4234755708 hasConcept C137555145 @default.
- W4234755708 hasConcept C153911025 @default.
- W4234755708 hasConcept C187882448 @default.
- W4234755708 hasConcept C206936463 @default.
- W4234755708 hasConcept C30481170 @default.
- W4234755708 hasConcept C54355233 @default.
- W4234755708 hasConcept C54815482 @default.
- W4234755708 hasConcept C6970260 @default.
- W4234755708 hasConcept C86803240 @default.
- W4234755708 hasConceptScore W4234755708C104317684 @default.
- W4234755708 hasConceptScore W4234755708C122735190 @default.
- W4234755708 hasConceptScore W4234755708C130693829 @default.
- W4234755708 hasConceptScore W4234755708C137555145 @default.
- W4234755708 hasConceptScore W4234755708C153911025 @default.
- W4234755708 hasConceptScore W4234755708C187882448 @default.
- W4234755708 hasConceptScore W4234755708C206936463 @default.
- W4234755708 hasConceptScore W4234755708C30481170 @default.
- W4234755708 hasConceptScore W4234755708C54355233 @default.
- W4234755708 hasConceptScore W4234755708C54815482 @default.
- W4234755708 hasConceptScore W4234755708C6970260 @default.
- W4234755708 hasConceptScore W4234755708C86803240 @default.
- W4234755708 hasIssue "7" @default.
- W4234755708 hasLocation W42347557081 @default.
- W4234755708 hasOpenAccess W4234755708 @default.
- W4234755708 hasPrimaryLocation W42347557081 @default.
- W4234755708 hasRelatedWork W1981383470 @default.
- W4234755708 hasRelatedWork W1981459085 @default.
- W4234755708 hasRelatedWork W1987377850 @default.
- W4234755708 hasRelatedWork W1996841578 @default.
- W4234755708 hasRelatedWork W2047508160 @default.
- W4234755708 hasRelatedWork W2055684572 @default.
- W4234755708 hasRelatedWork W2065393671 @default.
- W4234755708 hasRelatedWork W2416421268 @default.
- W4234755708 hasRelatedWork W26495077 @default.
- W4234755708 hasRelatedWork W4213148981 @default.
- W4234755708 hasVolume "80" @default.
- W4234755708 isParatext "false" @default.
- W4234755708 isRetracted "false" @default.
- W4234755708 workType "article" @default.