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- W4234774469 abstract "Sepsis is defined as life-threatening organ dysfunction resulting from an inappropriate host response to infection. Encephalopathy occurs in more than 30% of patients with sepsis and is associated with increased mortality and long-term psycho-cognitive disorders. Sepsis-associated encephalopathy (SAE) is characterized by impaired consciousness, ranging from delirium to coma, and by various electrophysiological changes, notably electrographic seizures in up to 15% of patients. Cerebral imaging can reveal white matter hyperintensities or ischemic stroke. Neuropathological examination often shows petechiae related to disseminated intravascular coagulation (DIC), axonal damage, and ischemia and, less often, abscesses in about 10% of cases. SAE is regarded as resulting from a combination of three mechanisms triggered by systemic inflammation: (i) neuroinflammation involving microglial cells activated by inflammatory mediators crossing a permeable blood-brain barrier (BBB); (ii) ischemia mainly related to macro- and microcirculatory dysfunction and DIC; (iii) neurotoxicity related to excitoxicity, mitochondrial dysfunction, and oxidative stress. There is no specific treatment for SAE, but treatment is aimed at general measures for controlling sepsis and preventing or treating delirium in patients who are critically ill." @default.
- W4234774469 created "2022-05-12" @default.
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- W4234774469 date "2020-01-10" @default.
- W4234774469 modified "2023-10-09" @default.
- W4234774469 title "Sepsis‐Associated Encephalopathy" @default.
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- W4234774469 doi "https://doi.org/10.1002/9781119467748.ch2" @default.
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