Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234778359> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4234778359 abstract "Abstract Background The occurrence of postoperative cognitive deficits, especially after heart surgery, has been demonstrated in several studies. These deficits can clearly be noticed by the patients as well as by their close relatives in daily life. Furthermore, postoperative cognitive deficits can decrease quality of life in social functioning and earning capacity. The aim of this study is to investigate whether early postoperative cognitive training can reduce subjective and objective postoperative cognitive deficits Methods The proposed study is a multicenter, 2-arm randomized controlled trial involving 144 elderly patients undergoing elective heart valve surgery with extracorporeal circulation. Patients will be assigned to either a training group or a control group. The intervention involves a paper-and-pencil-based cognitive training, which is conducted for 36 minutes over a period of 18 days. The training starts about 1 week after surgery and is carried out during the hospitalized rehabilitation phase. The control group will not receive a cognitive training or a placebo intervention. A detailed assessment of psychological functions and health-related quality of life prior to surgery at discharge from rehabilitation and 3 and 12 months after discharge will be performed. The Primary outcome of this trial is the training effect on objective cognitive functions at discharge from rehabilitation. Secondary outcomes are the training effect on objective and subjective cognitive functions (3 and 12 months after discharge), depression, health-related quality of life, and the impact of perioperative cerebral ischemia on the training effect. Perioperative cerebral ischemia will be measured with postoperative magnetic resonance imaging including diffusion-weighted sequences. Discussion Should it be shown that our cognitive training can improve postoperative cognitive deficits as well as quality of life, one possibility could be to integrate this intervention into early rehabilitation. Furthermore, we hope that the investigation of perioperative ischemia by diffusion-weighted magnetic resonance imaging will improve our understanding of neurobiological factors influencing the course of postoperative cognitive plasticity." @default.
- W4234778359 created "2022-05-12" @default.
- W4234778359 creator A5013540266 @default.
- W4234778359 creator A5014822238 @default.
- W4234778359 creator A5031141206 @default.
- W4234778359 creator A5031396606 @default.
- W4234778359 creator A5037302321 @default.
- W4234778359 creator A5040294363 @default.
- W4234778359 creator A5049579050 @default.
- W4234778359 creator A5051617218 @default.
- W4234778359 creator A5052763026 @default.
- W4234778359 creator A5060330435 @default.
- W4234778359 creator A5060916592 @default.
- W4234778359 creator A5072585260 @default.
- W4234778359 creator A5076540888 @default.
- W4234778359 creator A5085784398 @default.
- W4234778359 creator A5010949123 @default.
- W4234778359 date "2019-10-11" @default.
- W4234778359 modified "2023-09-28" @default.
- W4234778359 title "Decreasing postoperative cognitive deficits after heart surgery: Protocol for a randomized controlled trial on cognitive training" @default.
- W4234778359 doi "https://doi.org/10.21203/rs.2.12481/v2" @default.
- W4234778359 hasPublicationYear "2019" @default.
- W4234778359 type Work @default.
- W4234778359 citedByCount "0" @default.
- W4234778359 crossrefType "posted-content" @default.
- W4234778359 hasAuthorship W4234778359A5010949123 @default.
- W4234778359 hasAuthorship W4234778359A5013540266 @default.
- W4234778359 hasAuthorship W4234778359A5014822238 @default.
- W4234778359 hasAuthorship W4234778359A5031141206 @default.
- W4234778359 hasAuthorship W4234778359A5031396606 @default.
- W4234778359 hasAuthorship W4234778359A5037302321 @default.
- W4234778359 hasAuthorship W4234778359A5040294363 @default.
- W4234778359 hasAuthorship W4234778359A5049579050 @default.
- W4234778359 hasAuthorship W4234778359A5051617218 @default.
- W4234778359 hasAuthorship W4234778359A5052763026 @default.
- W4234778359 hasAuthorship W4234778359A5060330435 @default.
- W4234778359 hasAuthorship W4234778359A5060916592 @default.
- W4234778359 hasAuthorship W4234778359A5072585260 @default.
- W4234778359 hasAuthorship W4234778359A5076540888 @default.
- W4234778359 hasAuthorship W4234778359A5085784398 @default.
- W4234778359 hasBestOaLocation W42347783591 @default.
- W4234778359 hasConcept C118552586 @default.
- W4234778359 hasConcept C141071460 @default.
- W4234778359 hasConcept C159110408 @default.
- W4234778359 hasConcept C168563851 @default.
- W4234778359 hasConcept C169900460 @default.
- W4234778359 hasConcept C1862650 @default.
- W4234778359 hasConcept C2778818304 @default.
- W4234778359 hasConcept C2779602242 @default.
- W4234778359 hasConcept C2779951463 @default.
- W4234778359 hasConcept C2909801347 @default.
- W4234778359 hasConcept C31174226 @default.
- W4234778359 hasConcept C42219234 @default.
- W4234778359 hasConcept C68015696 @default.
- W4234778359 hasConcept C71924100 @default.
- W4234778359 hasConcept C99508421 @default.
- W4234778359 hasConceptScore W4234778359C118552586 @default.
- W4234778359 hasConceptScore W4234778359C141071460 @default.
- W4234778359 hasConceptScore W4234778359C159110408 @default.
- W4234778359 hasConceptScore W4234778359C168563851 @default.
- W4234778359 hasConceptScore W4234778359C169900460 @default.
- W4234778359 hasConceptScore W4234778359C1862650 @default.
- W4234778359 hasConceptScore W4234778359C2778818304 @default.
- W4234778359 hasConceptScore W4234778359C2779602242 @default.
- W4234778359 hasConceptScore W4234778359C2779951463 @default.
- W4234778359 hasConceptScore W4234778359C2909801347 @default.
- W4234778359 hasConceptScore W4234778359C31174226 @default.
- W4234778359 hasConceptScore W4234778359C42219234 @default.
- W4234778359 hasConceptScore W4234778359C68015696 @default.
- W4234778359 hasConceptScore W4234778359C71924100 @default.
- W4234778359 hasConceptScore W4234778359C99508421 @default.
- W4234778359 hasLocation W42347783591 @default.
- W4234778359 hasLocation W42347783592 @default.
- W4234778359 hasLocation W42347783593 @default.
- W4234778359 hasOpenAccess W4234778359 @default.
- W4234778359 hasPrimaryLocation W42347783591 @default.
- W4234778359 hasRelatedWork W1974113503 @default.
- W4234778359 hasRelatedWork W2496985065 @default.
- W4234778359 hasRelatedWork W2965756149 @default.
- W4234778359 hasRelatedWork W2982414836 @default.
- W4234778359 hasRelatedWork W3005722021 @default.
- W4234778359 hasRelatedWork W3029713626 @default.
- W4234778359 hasRelatedWork W3165938456 @default.
- W4234778359 hasRelatedWork W36976070 @default.
- W4234778359 hasRelatedWork W4223505544 @default.
- W4234778359 hasRelatedWork W4225834507 @default.
- W4234778359 isParatext "false" @default.
- W4234778359 isRetracted "false" @default.
- W4234778359 workType "article" @default.