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- W4234875595 abstract "Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy (TMA) which is the result of a severe deficiency of ADAMTS13 activity. In the majority of cases, the ADAMTS13 deficiency is the result of auto-antibodies produced against ADAMTS13 which impair protein activity. With the recognition and characterisation of the pathological basis of acquired TTP has come rational therapies including more targeted and less toxic immunosuppression (e.g. rituximab), targeted agents against the vWF platelet interaction (caplacizumab) and recombinant ADAMTS13. The Australian TTP/TMA registry was established to collect data on Australian patients with all TMAs with the aim of creating a resource to help assess the patterns of diagnosis and management of this group of disorders in Australia. The registry is maintained by the Monash University Department of Epidemiology and Preventive Medicine (DEPM) under the auspices of the Transfusion Outcomes Research Collaboration, a partnership with the Australian Red Cross Blood Service (ARCBS), and began collecting data in 2009. Analysis of data from patients with TTP in the TTP/TMA registry has given insights into the current state of diagnosis and treatment of TTP in Australian patients and identified potential areas for practice improvement which will be shared in this presentation." @default.
- W4234875595 created "2022-05-12" @default.
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- W4234875595 date "2016-02-01" @default.
- W4234875595 modified "2023-09-25" @default.
- W4234875595 title "An update on TTP including data from the Australian TTP/TMA registry" @default.
- W4234875595 doi "https://doi.org/10.1016/j.pathol.2015.12.117" @default.
- W4234875595 hasPublicationYear "2016" @default.
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