FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234882375> ?p ?o ?g. }

• W4234882375 endingPage "A49" @default.
• W4234882375 startingPage "A48.3" @default.
• W4234882375 abstract "<h3>Background and Objectives</h3> Identification of biomarkers for early diagnosis and treatment response would be beneficial for patients with early rheumatoid arthritis (ERA) to prevent ongoing joint damage. MiRNAs have features of potential biomarkers and an altered expression of miRNAs was shown in established RA. Our aim was to analyse RA-associated miR-223 and miR-16 in sera from patients with ERA to find markers of early disease, clinical activity or predictors of disease outcome. <h3>Materials and Methods</h3> Clinical characteristics were obtained in 34 patients with ERA at baseline and after 3 (M3) and 12 (M12) months therapy with DMARDs. Total RNA was isolated using phenol-chloroform extraction from whole sera obtained at baseline and M3. Peripheral blood mononuclear cells (PBMC) from healthy donors were treated with methotrexate (MTX, 25 ug/ml) in vitro. Expression of miR-223 and miR-16 was analysed by TaqMan Real-time PCR. <h3>Results</h3> Levels of miR-223 significantly decreased following therapy (p = 0.002). In treatment naïve patients with ERA, the expression of miR-223 positively correlated with baseline DAS28 (p = 0.031), change in DAS28 (∆DAS28) from baseline to M3 (p = 0.014), baseline CRP (p = 0.008) and count of peripheral leukocytes (p = 0.007). The change in expression of miR-223 in sera may be attributable to the change in the count of leukocytes between baseline and M3 concluded from the positive correlations between these variables (p = 0.025). In addition, the expression of miR-223 in PBMC was down regulated by 15% (p = 0.001) after treatment with MTX. Levels of miR-16 significantly increased (p = 0.008) after 3 months of therapy and the increase in miR-16 was associated with the decrease in DAS28 from M3 to M12 (p = 0.002). <h3>Conclusions</h3> Our data support the potential of miR-223 to serve as a marker of disease activity in patients with treatment naïve ERA. Moreover, monitoring levels of miR-16 and miR-223 may become a useful tool to predict the disease outcome in patients with ERA. <h3>Acknowledgement</h3> This work was supported by IMI BTCure, IAR, Masterswitch-PF7, Articulum, OPPA and MH CR project No. 023728." @default.
• W4234882375 created "2022-05-12" @default.
• W4234882375 creator A5002907433 @default.
• W4234882375 creator A5014212884 @default.
• W4234882375 creator A5019763858 @default.
• W4234882375 creator A5027428785 @default.
• W4234882375 creator A5029329633 @default.
• W4234882375 creator A5031588644 @default.
• W4234882375 creator A5040096657 @default.
• W4234882375 creator A5045466634 @default.
• W4234882375 creator A5072111802 @default.
• W4234882375 creator A5081760061 @default.
• W4234882375 creator A5089477356 @default.
• W4234882375 date "2013-02-25" @default.
• W4234882375 modified "2023-10-13" @default.
• W4234882375 title "A7.3 Association of Circulating miR-223 and miR-16 with Disease Activity in Patients with Early Rheumatoid Arthritis" @default.
• W4234882375 doi "https://doi.org/10.1136/annrheumdis-2013-203221.3" @default.
• W4234882375 hasPublicationYear "2013" @default.
• W4234882375 type Work @default.
• W4234882375 citedByCount "0" @default.
• W4234882375 crossrefType "journal-article" @default.
• W4234882375 hasAuthorship W4234882375A5002907433 @default.
• W4234882375 hasAuthorship W4234882375A5014212884 @default.
• W4234882375 hasAuthorship W4234882375A5019763858 @default.
• W4234882375 hasAuthorship W4234882375A5027428785 @default.
• W4234882375 hasAuthorship W4234882375A5029329633 @default.
• W4234882375 hasAuthorship W4234882375A5031588644 @default.
• W4234882375 hasAuthorship W4234882375A5040096657 @default.
• W4234882375 hasAuthorship W4234882375A5045466634 @default.
• W4234882375 hasAuthorship W4234882375A5072111802 @default.
• W4234882375 hasAuthorship W4234882375A5081760061 @default.
• W4234882375 hasAuthorship W4234882375A5089477356 @default.
• W4234882375 hasBestOaLocation W42348823751 @default.
• W4234882375 hasConcept C126322002 @default.
• W4234882375 hasConcept C137061746 @default.
• W4234882375 hasConcept C143998085 @default.
• W4234882375 hasConcept C185592680 @default.
• W4234882375 hasConcept C202751555 @default.
• W4234882375 hasConcept C203014093 @default.
• W4234882375 hasConcept C2777077863 @default.
• W4234882375 hasConcept C2777575956 @default.
• W4234882375 hasConcept C2781059491 @default.
• W4234882375 hasConcept C2781197716 @default.
• W4234882375 hasConcept C55493867 @default.
• W4234882375 hasConcept C71924100 @default.
• W4234882375 hasConcept C90924648 @default.
• W4234882375 hasConceptScore W4234882375C126322002 @default.
• W4234882375 hasConceptScore W4234882375C137061746 @default.
• W4234882375 hasConceptScore W4234882375C143998085 @default.
• W4234882375 hasConceptScore W4234882375C185592680 @default.
• W4234882375 hasConceptScore W4234882375C202751555 @default.
• W4234882375 hasConceptScore W4234882375C203014093 @default.
• W4234882375 hasConceptScore W4234882375C2777077863 @default.
• W4234882375 hasConceptScore W4234882375C2777575956 @default.
• W4234882375 hasConceptScore W4234882375C2781059491 @default.
• W4234882375 hasConceptScore W4234882375C2781197716 @default.
• W4234882375 hasConceptScore W4234882375C55493867 @default.
• W4234882375 hasConceptScore W4234882375C71924100 @default.
• W4234882375 hasConceptScore W4234882375C90924648 @default.
• W4234882375 hasIssue "Suppl 1" @default.
• W4234882375 hasLocation W42348823751 @default.
• W4234882375 hasOpenAccess W4234882375 @default.
• W4234882375 hasPrimaryLocation W42348823751 @default.
• W4234882375 hasRelatedWork W1977601919 @default.
• W4234882375 hasRelatedWork W2001317021 @default.
• W4234882375 hasRelatedWork W2055140067 @default.
• W4234882375 hasRelatedWork W2159713565 @default.
• W4234882375 hasRelatedWork W2362264087 @default.
• W4234882375 hasRelatedWork W2413444422 @default.
• W4234882375 hasRelatedWork W2616933475 @default.
• W4234882375 hasRelatedWork W2806179142 @default.
• W4234882375 hasRelatedWork W2995476051 @default.
• W4234882375 hasRelatedWork W2612564893 @default.
• W4234882375 hasVolume "72" @default.
• W4234882375 isParatext "false" @default.
• W4234882375 isRetracted "false" @default.
• W4234882375 workType "article" @default.