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- W4234890117 abstract "Introduction: A pandemic is an epidemic occurring worldwide, crossing international boundaries and affecting many people. The spread of SARS-CoV-2 from Hubei province in China globally has led to rapid changes in our approaches to diagnosis, with rapid use of molecular methods such as whole genome sequencing (WGS) to characterise mutations, and deployment of novel therapeutics including mRNA vaccines and monoclonal antibodies. Methods: New methods for diagnosis, including WGS, and different approaches to emerging mutations in virus variants of concern (VOC) will be discussed. Results and conclusions: Diagnosis now uses standard molecular methods including commercial and inhouse techniques, more recently rapid antigen detection, and research into rapid smartphone based nanoparticle assays. Laboratory practices of sample pooling, reflex testing using WGS, and workflow changes are now routine. The use of rapid WGS techniques,1 and available Australian data,2,3 have informed assessment of the accuracy and utility of these methods in the diagnostic laboratory. Assessment of changes in PCR primer binding sites, and of the influence of how sequence data are assessed (Foster et al., in press) means accreditation and QA programs need to be continuously updated. References 1. Bull RA, Adikari TN, Ferguson JM, et al. Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis. Nat Commun 2020; 11: 6272. 2. Rockett RJ, Arnott A, Lam C, et al. Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modeling. Nat Med 2020; 26: 1398–404. 3. Seemann T, Lane CR, Sherry NL, et al. Tracking the COVID-19 pandemic in Australia using genomics. Nat Commun 2020; 11: 4376." @default.
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- W4234890117 date "2021-07-01" @default.
- W4234890117 modified "2023-09-25" @default.
- W4234890117 title "Background, testing methods, and laboratory approaches to sars coronavirus-2 (SARS-CoV-2) and covid19" @default.
- W4234890117 doi "https://doi.org/10.1016/j.pathol.2021.05.006" @default.
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