Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234902455> ?p ?o ?g. }
- W4234902455 endingPage "236" @default.
- W4234902455 startingPage "221" @default.
- W4234902455 abstract "A series of novel 4-aryl-pyrido[1,2-c]pyrimidine derivatives containing a 1-(2-quinoline)piperazine moiety was synthesized. The chemical structure of new compounds was confirmed by FT-IR, (1)H NMR, (13)C NMR and HRMS spectra as well as elemental analysis. Affinity of the novel pyrido[1,2-c]pyrimidine derivatives for 5-HT1A, 5-HT2A receptors and serotonin transporter (SERT) was evaluated in an in vitro radioligand binding assay. Tested compounds showed moderate to high affinity for 5-HT1AR and SERT and low affinity for 5-HT2AR. Selected ligands were subjected to in vivo tests, such as induced hypothermia and the forced swimming test in mice, which determined presynaptic agonistic activity of the ligands 8d, 8e, 9d and 9e and presynaptic antagonistic activity of the ligands 8a, 8b, 9a, 9b. Additionally, metabolic stability evaluation was performed for selected ligands, proving that a para-substitution in the 4-aryl-pyrido[1,2-c]pyrimidine moiety leads to an increase in stability, whereas a substitution in the ortho-position lowers the stability." @default.
- W4234902455 created "2022-05-12" @default.
- W4234902455 creator A5000215829 @default.
- W4234902455 creator A5002909012 @default.
- W4234902455 creator A5010055471 @default.
- W4234902455 creator A5017334559 @default.
- W4234902455 creator A5020755181 @default.
- W4234902455 creator A5025279851 @default.
- W4234902455 creator A5025399512 @default.
- W4234902455 creator A5035403793 @default.
- W4234902455 creator A5041900772 @default.
- W4234902455 creator A5044015773 @default.
- W4234902455 creator A5045857656 @default.
- W4234902455 creator A5061214637 @default.
- W4234902455 creator A5073293274 @default.
- W4234902455 creator A5075335933 @default.
- W4234902455 creator A5076417818 @default.
- W4234902455 creator A5079267163 @default.
- W4234902455 creator A5084240169 @default.
- W4234902455 creator A5085355095 @default.
- W4234902455 creator A5091854701 @default.
- W4234902455 date "2015-06-01" @default.
- W4234902455 modified "2023-10-18" @default.
- W4234902455 title "Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. Part 5" @default.
- W4234902455 cites W1525338767 @default.
- W4234902455 cites W1597920023 @default.
- W4234902455 cites W1965006436 @default.
- W4234902455 cites W1966173192 @default.
- W4234902455 cites W1967435433 @default.
- W4234902455 cites W1968912840 @default.
- W4234902455 cites W1969496029 @default.
- W4234902455 cites W1981991422 @default.
- W4234902455 cites W1995861693 @default.
- W4234902455 cites W1998088135 @default.
- W4234902455 cites W2001023145 @default.
- W4234902455 cites W2004241446 @default.
- W4234902455 cites W2007046516 @default.
- W4234902455 cites W2015893030 @default.
- W4234902455 cites W2016452663 @default.
- W4234902455 cites W2017221228 @default.
- W4234902455 cites W2022816995 @default.
- W4234902455 cites W2024678540 @default.
- W4234902455 cites W2026011772 @default.
- W4234902455 cites W2028877884 @default.
- W4234902455 cites W2033230112 @default.
- W4234902455 cites W2036812642 @default.
- W4234902455 cites W2037178067 @default.
- W4234902455 cites W2043676765 @default.
- W4234902455 cites W2047755689 @default.
- W4234902455 cites W2051057494 @default.
- W4234902455 cites W2054369150 @default.
- W4234902455 cites W2069180487 @default.
- W4234902455 cites W2074631079 @default.
- W4234902455 cites W2075623469 @default.
- W4234902455 cites W2086826579 @default.
- W4234902455 cites W2088874841 @default.
- W4234902455 cites W2089489115 @default.
- W4234902455 cites W2094368363 @default.
- W4234902455 cites W2094569992 @default.
- W4234902455 cites W2098761489 @default.
- W4234902455 cites W2103069395 @default.
- W4234902455 cites W2129140710 @default.
- W4234902455 cites W2150215731 @default.
- W4234902455 cites W2157177243 @default.
- W4234902455 cites W2169891500 @default.
- W4234902455 cites W2170381087 @default.
- W4234902455 cites W2178046296 @default.
- W4234902455 cites W2820275006 @default.
- W4234902455 cites W4236370376 @default.
- W4234902455 cites W4248107770 @default.
- W4234902455 doi "https://doi.org/10.1016/j.ejmech.2015.05.003" @default.
- W4234902455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26043160" @default.
- W4234902455 hasPublicationYear "2015" @default.
- W4234902455 type Work @default.
- W4234902455 citedByCount "13" @default.
- W4234902455 countsByYear W42349024552016 @default.
- W4234902455 countsByYear W42349024552017 @default.
- W4234902455 countsByYear W42349024552018 @default.
- W4234902455 countsByYear W42349024552019 @default.
- W4234902455 countsByYear W42349024552020 @default.
- W4234902455 countsByYear W42349024552021 @default.
- W4234902455 countsByYear W42349024552023 @default.
- W4234902455 crossrefType "journal-article" @default.
- W4234902455 hasAuthorship W4234902455A5000215829 @default.
- W4234902455 hasAuthorship W4234902455A5002909012 @default.
- W4234902455 hasAuthorship W4234902455A5010055471 @default.
- W4234902455 hasAuthorship W4234902455A5017334559 @default.
- W4234902455 hasAuthorship W4234902455A5020755181 @default.
- W4234902455 hasAuthorship W4234902455A5025279851 @default.
- W4234902455 hasAuthorship W4234902455A5025399512 @default.
- W4234902455 hasAuthorship W4234902455A5035403793 @default.
- W4234902455 hasAuthorship W4234902455A5041900772 @default.
- W4234902455 hasAuthorship W4234902455A5044015773 @default.
- W4234902455 hasAuthorship W4234902455A5045857656 @default.
- W4234902455 hasAuthorship W4234902455A5061214637 @default.
- W4234902455 hasAuthorship W4234902455A5073293274 @default.
- W4234902455 hasAuthorship W4234902455A5075335933 @default.
- W4234902455 hasAuthorship W4234902455A5076417818 @default.