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- W4234907447 abstract "Abstract Hepatorenal syndrome (HRS) occurs in patients with end-stage liver disease and results from the complex circulatory changes associated with cirrhosis, where splanchnic vasodilatation and effective hypovolemia play central roles. Although related to hypovolemia, HRS is not reversed by volume expansion. In theory, HRS is not associated with structural changes in the kidney and, thus, is fully reversible with liver transplantation. Improvement may be observed with vasoconstrictors such as terlipressin in combination with albumin. However, in the absence of transplantation, HRS is associated with an extremely poor prognosis, even in patients who respond to vasoconstrictors. It is important to differentiate HRS from acute tubular necrosis because the therapeutic approach to each is different. Recent biomarkers are helpful but do not allow a clear distinction." @default.
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- W4234907447 date "2019-02-01" @default.
- W4234907447 modified "2023-10-18" @default.
- W4234907447 title "Hepatorenal Syndrome" @default.
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- W4234907447 doi "https://doi.org/10.1093/med/9780190611620.003.0040" @default.
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