Matches in SemOpenAlex for { <https://semopenalex.org/work/W4234944145> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4234944145 abstract "In clinical samples, depression was reported to be associated with hippocampal volume loss. We sought to examine this in a population-based setting. Design: Cross-sectional study derived from the Mayo Clinic population-based Study of Aging in Olmsted County, Minnesota. Participants: cognitively normal subjects who had Magnetic Resonance Imaging (MRI) of the head and documented measures of depression constituted the sample for this study. Each MRI scan was graded for hippocampal volume, ventricular size, and white matter hyperintensity (WMH) severity, using a visual analog grading scale. Hippocampal and ventricular size were graded on 3D T1 weighted images while WMH was graded on FLAIR images. Depression was measured by using Beck Depressive Inventory (BDI-II). Statistical analysis: non-parametric rank based Spearman correlation was used to examine the association between the BDI score and hippocampal volume as well as ventricular volume and WMH. Data were available on 185 cognitively normal individuals with a mean (SD) age of 79 (5.5) years. 84 of them (45.4%) were females. The BDI score ranged from 0 to 20 (a score of ≤ 13 is normal, 14 to 20 is indicative of mild depression, 21 to 30 is moderate and > 30 severe depression). After adjusting for age, sex and education, there was no correlation between BDI score and hippocampal volume (r = 0.12, p = 0.1), BDI and ventricular volume (r = -0.03, p = 0.7), BDI and WMH (r= -0.05, p = 0.5). 1-No participant had a BDI score indicative of moderate or severe depression. 2- In cognitively normal elderly persons, we did not observe a significant association between mild depressive symptoms and hippocampal volume loss in a population-based setting. Study supported by: The National Institutes of Health (K01 MH68351, U01 AG06786, K01 AG028573, R02 AR30582, and R01NS33978), Bethesda, MD; Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program and the Harold Amos Medical Faculty Development Program." @default.
- W4234944145 created "2022-05-12" @default.
- W4234944145 creator A5005099850 @default.
- W4234944145 creator A5022452703 @default.
- W4234944145 creator A5030579684 @default.
- W4234944145 creator A5043583052 @default.
- W4234944145 creator A5045246745 @default.
- W4234944145 creator A5053703908 @default.
- W4234944145 creator A5058106909 @default.
- W4234944145 creator A5059027860 @default.
- W4234944145 creator A5066352714 @default.
- W4234944145 creator A5077933873 @default.
- W4234944145 creator A5088891117 @default.
- W4234944145 date "2009-07-01" @default.
- W4234944145 modified "2023-10-15" @default.
- W4234944145 title "P1-146: Hippocampal volume and depressive symptoms: a population-based neuroimaging study" @default.
- W4234944145 doi "https://doi.org/10.1016/j.jalz.2009.04.151" @default.
- W4234944145 hasPublicationYear "2009" @default.
- W4234944145 type Work @default.
- W4234944145 citedByCount "0" @default.
- W4234944145 crossrefType "journal-article" @default.
- W4234944145 hasAuthorship W4234944145A5005099850 @default.
- W4234944145 hasAuthorship W4234944145A5022452703 @default.
- W4234944145 hasAuthorship W4234944145A5030579684 @default.
- W4234944145 hasAuthorship W4234944145A5043583052 @default.
- W4234944145 hasAuthorship W4234944145A5045246745 @default.
- W4234944145 hasAuthorship W4234944145A5053703908 @default.
- W4234944145 hasAuthorship W4234944145A5058106909 @default.
- W4234944145 hasAuthorship W4234944145A5059027860 @default.
- W4234944145 hasAuthorship W4234944145A5066352714 @default.
- W4234944145 hasAuthorship W4234944145A5077933873 @default.
- W4234944145 hasAuthorship W4234944145A5088891117 @default.
- W4234944145 hasConcept C118552586 @default.
- W4234944145 hasConcept C126322002 @default.
- W4234944145 hasConcept C126838900 @default.
- W4234944145 hasConcept C139719470 @default.
- W4234944145 hasConcept C143409427 @default.
- W4234944145 hasConcept C146638467 @default.
- W4234944145 hasConcept C148762608 @default.
- W4234944145 hasConcept C15744967 @default.
- W4234944145 hasConcept C162324750 @default.
- W4234944145 hasConcept C164705383 @default.
- W4234944145 hasConcept C2776867660 @default.
- W4234944145 hasConcept C2779631380 @default.
- W4234944145 hasConcept C2908647359 @default.
- W4234944145 hasConcept C558461103 @default.
- W4234944145 hasConcept C58693492 @default.
- W4234944145 hasConcept C71924100 @default.
- W4234944145 hasConcept C99454951 @default.
- W4234944145 hasConceptScore W4234944145C118552586 @default.
- W4234944145 hasConceptScore W4234944145C126322002 @default.
- W4234944145 hasConceptScore W4234944145C126838900 @default.
- W4234944145 hasConceptScore W4234944145C139719470 @default.
- W4234944145 hasConceptScore W4234944145C143409427 @default.
- W4234944145 hasConceptScore W4234944145C146638467 @default.
- W4234944145 hasConceptScore W4234944145C148762608 @default.
- W4234944145 hasConceptScore W4234944145C15744967 @default.
- W4234944145 hasConceptScore W4234944145C162324750 @default.
- W4234944145 hasConceptScore W4234944145C164705383 @default.
- W4234944145 hasConceptScore W4234944145C2776867660 @default.
- W4234944145 hasConceptScore W4234944145C2779631380 @default.
- W4234944145 hasConceptScore W4234944145C2908647359 @default.
- W4234944145 hasConceptScore W4234944145C558461103 @default.
- W4234944145 hasConceptScore W4234944145C58693492 @default.
- W4234944145 hasConceptScore W4234944145C71924100 @default.
- W4234944145 hasConceptScore W4234944145C99454951 @default.
- W4234944145 hasFunder F4320332161 @default.
- W4234944145 hasIssue "4S_Part_7" @default.
- W4234944145 hasLocation W42349441451 @default.
- W4234944145 hasOpenAccess W4234944145 @default.
- W4234944145 hasPrimaryLocation W42349441451 @default.
- W4234944145 hasRelatedWork W1585453570 @default.
- W4234944145 hasRelatedWork W2089002674 @default.
- W4234944145 hasRelatedWork W2090695367 @default.
- W4234944145 hasRelatedWork W2607350717 @default.
- W4234944145 hasRelatedWork W2609967009 @default.
- W4234944145 hasRelatedWork W2748952813 @default.
- W4234944145 hasRelatedWork W2899084033 @default.
- W4234944145 hasRelatedWork W3030874049 @default.
- W4234944145 hasRelatedWork W3041980964 @default.
- W4234944145 hasRelatedWork W4305072803 @default.
- W4234944145 hasVolume "5" @default.
- W4234944145 isParatext "false" @default.
- W4234944145 isRetracted "false" @default.
- W4234944145 workType "article" @default.