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- W4234958199 abstract "Giant cell lesions (GCLs) are rare non-odontogenic osteolytic lesions that affect both maxillofacial and axial/appendicular skeletal structures. Aggressive lesions have a tendency to recur after surgical enucleation. To avoid en-bloc resection, adjuvant pharmacologic therapy has been used with local operative treatment. Based on the hypothesis that maxillofacial GCLs are proliferative vascular lesions and angiogenesis dependent, a protocol of at least 6 months subcutaneous interferon alpha-2a after enucleation sparing vital structures (ie. teeth and nerves) has been used since 1999 in collaboration with a hematologist/oncologist.1 The purpose of this study was to evaluate the long-term results of this standardized treatment regimen in a homogenous cohort of patients with aggressive GCLs of the maxillofacial skeleton." @default.
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- W4234958199 date "2015-09-01" @default.
- W4234958199 modified "2023-10-13" @default.
- W4234958199 title "Adjuvant Antiangiogenic Treatment for Aggressive Giant Cell Lesions of the Jaw - a 20-Year Experience at the Massachusetts General Hospital" @default.
- W4234958199 doi "https://doi.org/10.1016/j.joms.2015.06.073" @default.
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