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- W4234966581 abstract "In this study we analysed the effect of overexpressing novel protein kinase C δ isoform (n-PKC δ) on melanin synthesis and metastatic potential in the highly metastatic BL6 murine melanoma cells. The proliferative capacityin vitroand into matrigelin vivowere also examined. Although murine melanocytes express the n-PKC δ isoform, BL6 cells do not express this isoform at levels detectable by Western blot analysis. In untransfected and transfected cells we also studied the effect of 12-O-tetra-decanoylphorbol-13-acetate (TPA), a modulator of specific isoforms of PKC, and of bryostatin 1, a potent immunomodulator and antineoplastic drug and a partial agonist of PKC. Our results demonstrate a pivotal role for this isoform in melanin synthesis and the close relationship between n-PKC δ expression and its association with the particulate fraction, melanogenesis and metastatic potential. In fact, heterogeneous BL6 cells overexpressing n-PKC δ and all the clones isolated showed increased intracellular melanin and metastatic capacity. TPA and bryostatin 1 decreased n-PKC δ expression, the intracellular melanin level and metastatic capacity in both cell lines. Therefore both treatments were able to abolish the effects of overexpressing n-PKC δ." @default.
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- W4234966581 date "2000-04-01" @default.
- W4234966581 modified "2023-09-29" @default.
- W4234966581 title "Overexpression of novel protein kinase C δ in BL6 murine melanoma cells inhibits the proliferative capacity in vitro but enhances the metastatic potential in vivo" @default.
- W4234966581 doi "https://doi.org/10.1097/00008390-200010020-00001" @default.
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