Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235002302> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W4235002302 abstract "Front cover: Confocal microscopy image of in vitro co-culture of Schwann cells and dorsal root ganglia (DRG) neurons, treated with the neuroactive steroid allopregnanolone (ALLO). Immunofluorescent labelling of Schwann cells and DRG neurite was performed with specific markers anti-myelin basic protein (green) and anti-neurofilament H (SMI31 in red), respectively; nuclei are stained with DAPI, in blue. A 21-days treatment of co-cultures with ALLO 10-6 M stimulates in vitro myelination, as shown by the merge colocalization in yellow. Overall, we proved that ALLO is active in regulating Schwann cells biological functions, such as proliferation, motility, morphological rearrangements and also myelination. These actions are GABA-A receptor mediated and involve the activation of Src and phospho-FAK kinases (see Melfi S. et al. this issue). The comprehension of these mechanisms may be of potential interest to develop new therapies for the peripheral neuropathies. We wish to thank Dr. Deborah Colleoni for the assistance for image preparation. Read the full article ‘Src and phospho-FAK kinases are activated by allopregnanolone promoting Schwann cell motility, morphology and myelination’ by S. Melfi, M. M. Montt Guevara, V. Bonalume, M. Ruscica, A. Colciago, T. Simoncini and V. Magnaghi (J. Neurochem. 2017, vol. 141 (2), pp. 165-178) on doi: 10.1111/jnc.13951" @default.
- W4235002302 created "2022-05-12" @default.
- W4235002302 date "2017-04-01" @default.
- W4235002302 modified "2023-10-18" @default.
- W4235002302 title "Issue Cover (April 2017)" @default.
- W4235002302 doi "https://doi.org/10.1111/jnc.13795" @default.
- W4235002302 hasPublicationYear "2017" @default.
- W4235002302 type Work @default.
- W4235002302 citedByCount "0" @default.
- W4235002302 crossrefType "journal-article" @default.
- W4235002302 hasBestOaLocation W42350023021 @default.
- W4235002302 hasConcept C113246987 @default.
- W4235002302 hasConcept C153911025 @default.
- W4235002302 hasConcept C169760540 @default.
- W4235002302 hasConcept C185323287 @default.
- W4235002302 hasConcept C202751555 @default.
- W4235002302 hasConcept C40209533 @default.
- W4235002302 hasConcept C55493867 @default.
- W4235002302 hasConcept C62478195 @default.
- W4235002302 hasConcept C86803240 @default.
- W4235002302 hasConcept C95444343 @default.
- W4235002302 hasConceptScore W4235002302C113246987 @default.
- W4235002302 hasConceptScore W4235002302C153911025 @default.
- W4235002302 hasConceptScore W4235002302C169760540 @default.
- W4235002302 hasConceptScore W4235002302C185323287 @default.
- W4235002302 hasConceptScore W4235002302C202751555 @default.
- W4235002302 hasConceptScore W4235002302C40209533 @default.
- W4235002302 hasConceptScore W4235002302C55493867 @default.
- W4235002302 hasConceptScore W4235002302C62478195 @default.
- W4235002302 hasConceptScore W4235002302C86803240 @default.
- W4235002302 hasConceptScore W4235002302C95444343 @default.
- W4235002302 hasIssue "2" @default.
- W4235002302 hasLocation W42350023021 @default.
- W4235002302 hasOpenAccess W4235002302 @default.
- W4235002302 hasPrimaryLocation W42350023021 @default.
- W4235002302 hasRelatedWork W1983021259 @default.
- W4235002302 hasRelatedWork W2007141251 @default.
- W4235002302 hasRelatedWork W2032251097 @default.
- W4235002302 hasRelatedWork W2038348068 @default.
- W4235002302 hasRelatedWork W2058336160 @default.
- W4235002302 hasRelatedWork W2081011614 @default.
- W4235002302 hasRelatedWork W2143296243 @default.
- W4235002302 hasRelatedWork W2150647809 @default.
- W4235002302 hasRelatedWork W3005078839 @default.
- W4235002302 hasRelatedWork W4235002302 @default.
- W4235002302 hasVolume "141" @default.
- W4235002302 isParatext "false" @default.
- W4235002302 isRetracted "false" @default.
- W4235002302 workType "article" @default.