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- W4235018051 abstract "Borrowing from the carcinogenesis field, the natural history of Sjögrens syndrome (SS) is analyzed from an evolutionary and multistage point of view. SS is divided into three stages called initiation, promotion and progression. The first stage may be asymptomatic and characterized only by serum autoantibodies (e.g. anti-Ro). The second stage is clinical autoimmune exocrinopathy with potential for lymphocyte aggressive behavior, extraglandular tissue infiltration and pseudolymphoma. The final stage is malignant lymphoma. This sequence is compared with the natural history of human immunodeficiency virus infection which also progresses from an asymptomatic state through AIDS-related complex to AIDS. Indeed, some HIV-infected patients have developed a clinical picture resembling SS due to salivary gland lymphoid infiltrates. This relatively new finding suggests a possible viral etiology for SS. The Epstein Barr virus must be considered in this context in view of (1) the history of infectious mononucleosis in many SS patients, (2) the production of an autocrine B-cell growth factor by B-cell lines established from SS patients, and (3) the development of EBV-related lymphomas in AIDS patients. If not itself the initiating agent, EBV may yet play an important role in maintaining the state of B-cell proliferation which progresses through autoimmunity into lymphoma in SS." @default.
- W4235018051 created "2022-05-12" @default.
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- W4235018051 date "1989-01-01" @default.
- W4235018051 modified "2023-10-18" @default.
- W4235018051 title "Maintenance of Autoimmunity" @default.
- W4235018051 doi "https://doi.org/10.1016/b978-0-12-069860-8.50022-0" @default.
- W4235018051 hasPublicationYear "1989" @default.
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