FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235043012> ?p ?o ?g. }

• W4235043012 abstract "The National Cancer Institute (USA) alert in February 1999 stated that concomitant chemoradiotherapy should be considered for all patients with cervical cancer, based on evidence from five randomised controlled trials.To review all known randomised clinical controlled trials (RCTs) comparing concomitant chemotherapy and radiation therapy with radiotherapy for locally advanced cervical cancer.We searched electronic databases, trials registers and reference lists of published trial reports and review articles were also searched.This review includes RCTs in cervical cancer comparing concomitant chemotherapy and radiotherapy with radiotherapy. In the experimental arm, further adjuvant chemotherapy was allowable. Hydroxyurea was considered inactive and allowable. Trials using radiosensitisers or radioprotectors in the experimental arm were excluded.Two authors reviewed trials for inclusion and extracted data. For meta-analyses of time-to-event outcomes (survival, progression-free survival), a hazard ratio (HR) was extracted or estimated from trial reports, where possible. Only overall rates of local and distant recurrence were presented in many reports so only an odds ratios (OR) of recurrence rates could be calculated, which takes no account of time to recurrence or censoring. The HRs and ORs for individual trials were combined across all trials, using the fixed effect model. Few trials reported acute toxicity adequately. Data were therefore grouped and the number of toxic events was used to calculate a single OR for each site and grade. Late toxicity was rarely described so could only be reviewed qualitatively.Nineteen trials (17 published, two unpublished) were identified including 4580 patients, although due to patient exclusion and differential reporting 62-78% were available for the various analyses. The review strongly suggests chemoradiation improves overall survival and progression free survival, whether platinum was used or not with absolute benefits of 12% and 16% respectively. There was, however, statistical heterogeneity for these outcomes There was some evidence that the effect was greater in trials including a high proportion of stage I and II patients. Chemoradiation also showed significant benefit for both local and distant recurrence. Haematological and gastrointestinal toxicity was significantly greater in the concomitant chemoradiation group. Details of late morbidity were sparse.Concomitant chemotherapy and radiotherapy appears to improve overall survival and progression-free survival in locally advanced cervical cancer. It also reduces local and distant recurrence suggesting concomitant chemotherapy may afford cytotoxic and sensitisation effects. Some acute toxicity is increased, but data on long term side effects were sparse." @default.
• W4235043012 created "2022-05-12" @default.
• W4235043012 creator A5022687403 @default.
• W4235043012 creator A5036613496 @default.
• W4235043012 creator A5043240913 @default.
• W4235043012 creator A5048264018 @default.
• W4235043012 creator A5058088465 @default.
• W4235043012 creator A5072073780 @default.
• W4235043012 creator A5086931161 @default.
• W4235043012 date "2001-10-23" @default.
• W4235043012 modified "2023-09-27" @default.
• W4235043012 title "Concomitant chemotherapy and radiation therapy for cancer of the uterine cervix" @default.
• W4235043012 cites W1907932102 @default.
• W4235043012 cites W1935824237 @default.
• W4235043012 cites W1966185142 @default.
• W4235043012 cites W1966953116 @default.
• W4235043012 cites W1969576509 @default.
• W4235043012 cites W1971653050 @default.
• W4235043012 cites W1977280396 @default.
• W4235043012 cites W1984363009 @default.
• W4235043012 cites W1985324368 @default.
• W4235043012 cites W1987186805 @default.
• W4235043012 cites W1989015712 @default.
• W4235043012 cites W1990227629 @default.
• W4235043012 cites W1993717128 @default.
• W4235043012 cites W2001154579 @default.
• W4235043012 cites W2004169137 @default.
• W4235043012 cites W2023454467 @default.
• W4235043012 cites W2025029957 @default.
• W4235043012 cites W2030438219 @default.
• W4235043012 cites W2034678824 @default.
• W4235043012 cites W2042312061 @default.
• W4235043012 cites W2048656597 @default.
• W4235043012 cites W2057806510 @default.
• W4235043012 cites W2063619884 @default.
• W4235043012 cites W2064223985 @default.
• W4235043012 cites W2075642745 @default.
• W4235043012 cites W2105700959 @default.
• W4235043012 cites W2111497441 @default.
• W4235043012 cites W2112339576 @default.
• W4235043012 cites W2120405223 @default.
• W4235043012 cites W2152292894 @default.
• W4235043012 cites W2153471759 @default.
• W4235043012 cites W2157719711 @default.
• W4235043012 cites W2158379591 @default.
• W4235043012 cites W2159878950 @default.
• W4235043012 cites W2264252006 @default.
• W4235043012 cites W2275599683 @default.
• W4235043012 cites W2314753133 @default.
• W4235043012 cites W2323195311 @default.
• W4235043012 cites W2324392028 @default.
• W4235043012 cites W2325379793 @default.
• W4235043012 cites W2328935341 @default.
• W4235043012 cites W2412843533 @default.
• W4235043012 cites W4210704032 @default.
• W4235043012 cites W4234573374 @default.
• W4235043012 cites W4239714259 @default.
• W4235043012 cites W4251656587 @default.
• W4235043012 cites W79049299 @default.
• W4235043012 doi "https://doi.org/10.1002/14651858.cd002225" @default.
• W4235043012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11687152" @default.
• W4235043012 hasPublicationYear "2001" @default.
• W4235043012 type Work @default.
• W4235043012 citedByCount "12" @default.
• W4235043012 countsByYear W42350430122012 @default.
• W4235043012 countsByYear W42350430122013 @default.
• W4235043012 countsByYear W42350430122016 @default.
• W4235043012 countsByYear W42350430122018 @default.
• W4235043012 countsByYear W42350430122022 @default.
• W4235043012 crossrefType "reference-entry" @default.
• W4235043012 hasAuthorship W4235043012A5022687403 @default.
• W4235043012 hasAuthorship W4235043012A5036613496 @default.
• W4235043012 hasAuthorship W4235043012A5043240913 @default.
• W4235043012 hasAuthorship W4235043012A5048264018 @default.
• W4235043012 hasAuthorship W4235043012A5058088465 @default.
• W4235043012 hasAuthorship W4235043012A5072073780 @default.
• W4235043012 hasAuthorship W4235043012A5086931161 @default.
• W4235043012 hasConcept C121608353 @default.
• W4235043012 hasConcept C126322002 @default.
• W4235043012 hasConcept C141071460 @default.
• W4235043012 hasConcept C143998085 @default.
• W4235043012 hasConcept C168563851 @default.
• W4235043012 hasConcept C207103383 @default.
• W4235043012 hasConcept C2777740455 @default.
• W4235043012 hasConcept C2778220009 @default.
• W4235043012 hasConcept C2779384505 @default.
• W4235043012 hasConcept C44249647 @default.
• W4235043012 hasConcept C509974204 @default.
• W4235043012 hasConcept C535046627 @default.
• W4235043012 hasConcept C71924100 @default.
• W4235043012 hasConceptScore W4235043012C121608353 @default.
• W4235043012 hasConceptScore W4235043012C126322002 @default.
• W4235043012 hasConceptScore W4235043012C141071460 @default.
• W4235043012 hasConceptScore W4235043012C143998085 @default.
• W4235043012 hasConceptScore W4235043012C168563851 @default.
• W4235043012 hasConceptScore W4235043012C207103383 @default.
• W4235043012 hasConceptScore W4235043012C2777740455 @default.
• W4235043012 hasConceptScore W4235043012C2778220009 @default.
• W4235043012 hasConceptScore W4235043012C2779384505 @default.
• W4235043012 hasConceptScore W4235043012C44249647 @default.

• next