Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235056399> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4235056399 endingPage "629a" @default.
- W4235056399 startingPage "629a" @default.
- W4235056399 abstract "The free energy that drives growth, resorption and sliding of focal adhesions includes mechanical and chemical contributions. We have identified a competition among four effects that control focal adhesion dynamics: (1) work done during addition of complexes, (2) the chemical potential inherent to focal adhesions, (3) the elastic free energy associated with deformation of focal adhesions, and (4) work done on a molecular conformational change. A theoretical treatment of focal adhesion dynamics developed in the framework of rate processes driven by thermodynamics demonstrates that the mechanisms governed by these four effects allow focal adhesions to exhibit a rich variety of behavior without the need to introduce special constitutive assumptions. In this treatment, the structural unit of focal adhesions is a complex consisting of a ligand such as fibronectin, an integrin molecule, and associated plaque proteins. The binding and unbinding of these complexes causes focal adhesion growth and resorption, respectively. The reaction-limited case is considered. Our central findings are that growth, resorption and sliding are all predicted by a very simple chemo-mechanical model. Sliding requires symmetry breaking and is achieved via (1) above; (4) promotes symmetric growth, and (2) and (3) cause symmetric desorption. The role of kinetic modulation is also examined." @default.
- W4235056399 created "2022-05-12" @default.
- W4235056399 creator A5018123365 @default.
- W4235056399 creator A5021953749 @default.
- W4235056399 creator A5034292983 @default.
- W4235056399 creator A5052274403 @default.
- W4235056399 date "2009-02-01" @default.
- W4235056399 modified "2023-09-26" @default.
- W4235056399 title "Professor" @default.
- W4235056399 doi "https://doi.org/10.1016/j.bpj.2008.12.3327" @default.
- W4235056399 hasPublicationYear "2009" @default.
- W4235056399 type Work @default.
- W4235056399 citedByCount "0" @default.
- W4235056399 crossrefType "journal-article" @default.
- W4235056399 hasAuthorship W4235056399A5018123365 @default.
- W4235056399 hasAuthorship W4235056399A5021953749 @default.
- W4235056399 hasAuthorship W4235056399A5034292983 @default.
- W4235056399 hasAuthorship W4235056399A5052274403 @default.
- W4235056399 hasBestOaLocation W42350563991 @default.
- W4235056399 hasConcept C12554922 @default.
- W4235056399 hasConcept C134018914 @default.
- W4235056399 hasConcept C146562846 @default.
- W4235056399 hasConcept C147597530 @default.
- W4235056399 hasConcept C151166631 @default.
- W4235056399 hasConcept C159467904 @default.
- W4235056399 hasConcept C170493617 @default.
- W4235056399 hasConcept C178790620 @default.
- W4235056399 hasConcept C185592680 @default.
- W4235056399 hasConcept C189165786 @default.
- W4235056399 hasConcept C195687474 @default.
- W4235056399 hasConcept C55493867 @default.
- W4235056399 hasConcept C59593255 @default.
- W4235056399 hasConcept C62478195 @default.
- W4235056399 hasConcept C84416704 @default.
- W4235056399 hasConcept C86492073 @default.
- W4235056399 hasConcept C86803240 @default.
- W4235056399 hasConceptScore W4235056399C12554922 @default.
- W4235056399 hasConceptScore W4235056399C134018914 @default.
- W4235056399 hasConceptScore W4235056399C146562846 @default.
- W4235056399 hasConceptScore W4235056399C147597530 @default.
- W4235056399 hasConceptScore W4235056399C151166631 @default.
- W4235056399 hasConceptScore W4235056399C159467904 @default.
- W4235056399 hasConceptScore W4235056399C170493617 @default.
- W4235056399 hasConceptScore W4235056399C178790620 @default.
- W4235056399 hasConceptScore W4235056399C185592680 @default.
- W4235056399 hasConceptScore W4235056399C189165786 @default.
- W4235056399 hasConceptScore W4235056399C195687474 @default.
- W4235056399 hasConceptScore W4235056399C55493867 @default.
- W4235056399 hasConceptScore W4235056399C59593255 @default.
- W4235056399 hasConceptScore W4235056399C62478195 @default.
- W4235056399 hasConceptScore W4235056399C84416704 @default.
- W4235056399 hasConceptScore W4235056399C86492073 @default.
- W4235056399 hasConceptScore W4235056399C86803240 @default.
- W4235056399 hasIssue "3" @default.
- W4235056399 hasLocation W42350563991 @default.
- W4235056399 hasOpenAccess W4235056399 @default.
- W4235056399 hasPrimaryLocation W42350563991 @default.
- W4235056399 hasRelatedWork W2055120717 @default.
- W4235056399 hasRelatedWork W2064977142 @default.
- W4235056399 hasRelatedWork W2071603490 @default.
- W4235056399 hasRelatedWork W2082050649 @default.
- W4235056399 hasRelatedWork W2107151297 @default.
- W4235056399 hasRelatedWork W2114045368 @default.
- W4235056399 hasRelatedWork W2129695120 @default.
- W4235056399 hasRelatedWork W2143920361 @default.
- W4235056399 hasRelatedWork W2767469072 @default.
- W4235056399 hasRelatedWork W4245127809 @default.
- W4235056399 hasVolume "96" @default.
- W4235056399 isParatext "false" @default.
- W4235056399 isRetracted "false" @default.
- W4235056399 workType "article" @default.