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- W4235137923 abstract "Recent advances in understanding the molecular biology of Alzheimer’s disease (AD) offer the promise of useful therapeutic intervention in the foreseeable future. Hence, improved methods for early diagnosis and noninvasive surrogates of disease severity in AD have become more imperative. Various quantitative magnetic resonance (MR) techniques that measure the anatomic, biochemical, microstructural, functional, and blood-flow changes are being evaluated as possible surrogate measures of disease progression. Cross-sectional and longitudinal studies indicate that MR-based volume measurements are potential surrogates of disease progression in AD, starting from the preclinical stages. The validity of MR-based volumetry as a surrogate marker for therapeutic efficacy in AD remains to be tested in a positive disease-modifying drug trial. Recent development of amyloid imaging tracers for positron emission tomography has been a major breakthrough in the field of imaging markers for AD. Efforts to image plaques are also underway in MR imaging. As with indirect MR measures, these approaches of directly imaging the pathological substrate will need to undergo a validation process with longitudinal studies to prove their usefulness as surrogate markers in AD." @default.
- W4235137923 created "2022-05-12" @default.
- W4235137923 creator A5005099850 @default.
- W4235137923 creator A5077933873 @default.
- W4235137923 date "2004-04-01" @default.
- W4235137923 modified "2023-09-26" @default.
- W4235137923 title "Quantitative magnetic resonance techniques as surrogate markers of Alzheimer’s disease" @default.
- W4235137923 cites W1745420251 @default.
- W4235137923 cites W1964142865 @default.
- W4235137923 cites W1966378897 @default.
- W4235137923 cites W1966853594 @default.
- W4235137923 cites W1968858374 @default.
- W4235137923 cites W1970240370 @default.
- W4235137923 cites W1975301973 @default.
- W4235137923 cites W1978509870 @default.
- W4235137923 cites W1980842500 @default.
- W4235137923 cites W1980852792 @default.
- W4235137923 cites W1981190087 @default.
- W4235137923 cites W1983139353 @default.
- W4235137923 cites W1985603549 @default.
- W4235137923 cites W1985612893 @default.
- W4235137923 cites W1991886821 @default.
- W4235137923 cites W1992816826 @default.
- W4235137923 cites W1993812357 @default.
- W4235137923 cites W1996433268 @default.
- W4235137923 cites W1996722919 @default.
- W4235137923 cites W1998752180 @default.
- W4235137923 cites W1999601856 @default.
- W4235137923 cites W2002894520 @default.
- W4235137923 cites W2007284815 @default.
- W4235137923 cites W2009739635 @default.
- W4235137923 cites W2011452438 @default.
- W4235137923 cites W2012133068 @default.
- W4235137923 cites W2013292302 @default.
- W4235137923 cites W2014247959 @default.
- W4235137923 cites W2014909648 @default.
- W4235137923 cites W2018009442 @default.
- W4235137923 cites W2019541714 @default.
- W4235137923 cites W2021913585 @default.
- W4235137923 cites W2022233688 @default.
- W4235137923 cites W2023798788 @default.
- W4235137923 cites W2024448927 @default.
- W4235137923 cites W2028989537 @default.
- W4235137923 cites W2030762224 @default.
- W4235137923 cites W2033800655 @default.
- W4235137923 cites W2036162736 @default.
- W4235137923 cites W2036622325 @default.
- W4235137923 cites W2040853845 @default.
- W4235137923 cites W2042514413 @default.
- W4235137923 cites W2044367669 @default.
- W4235137923 cites W2046429594 @default.
- W4235137923 cites W2049105183 @default.
- W4235137923 cites W2049362778 @default.
- W4235137923 cites W2052742260 @default.
- W4235137923 cites W2060786719 @default.
- W4235137923 cites W2063136428 @default.
- W4235137923 cites W2064077759 @default.
- W4235137923 cites W2069027292 @default.
- W4235137923 cites W2070181269 @default.
- W4235137923 cites W2070477842 @default.
- W4235137923 cites W2071831557 @default.
- W4235137923 cites W2077047597 @default.
- W4235137923 cites W2084787525 @default.
- W4235137923 cites W2086136360 @default.
- W4235137923 cites W2086978209 @default.
- W4235137923 cites W2089588548 @default.
- W4235137923 cites W2090798299 @default.
- W4235137923 cites W2091022458 @default.
- W4235137923 cites W2092677917 @default.
- W4235137923 cites W2094542668 @default.
- W4235137923 cites W2095102390 @default.
- W4235137923 cites W2095868324 @default.
- W4235137923 cites W2101861019 @default.
- W4235137923 cites W2102932131 @default.
- W4235137923 cites W2113708991 @default.
- W4235137923 cites W2115077024 @default.
- W4235137923 cites W2115424422 @default.
- W4235137923 cites W2117602475 @default.
- W4235137923 cites W2117957004 @default.
- W4235137923 cites W2121544226 @default.
- W4235137923 cites W2121925748 @default.
- W4235137923 cites W2122169108 @default.
- W4235137923 cites W2124114508 @default.
- W4235137923 cites W2128776571 @default.
- W4235137923 cites W2134547791 @default.
- W4235137923 cites W2136579519 @default.
- W4235137923 cites W2138250005 @default.
- W4235137923 cites W2139336856 @default.
- W4235137923 cites W2140542463 @default.
- W4235137923 cites W2143854933 @default.
- W4235137923 cites W2145858412 @default.
- W4235137923 cites W2149142893 @default.
- W4235137923 cites W2149614271 @default.
- W4235137923 cites W2152634927 @default.
- W4235137923 cites W2153631628 @default.
- W4235137923 cites W2159122349 @default.
- W4235137923 cites W2159789463 @default.
- W4235137923 cites W2162319029 @default.