Matches in SemOpenAlex for { <https://semopenalex.org/work/W4235206572> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4235206572 endingPage "3394" @default.
- W4235206572 startingPage "3387" @default.
- W4235206572 abstract "The soluble form of the insulin-like growth factor-II/mannose 6-phosphate receptor, which has been detected in serum from a variety of species, is synthesized and released by rat tissue explants in culture. Investigations into its regulation and function, however, have been hampered by inadequate means of quantification. In this paper a RIA that enables sensitive and specific quantification of soluble receptor from serum and conditioned medium is described. In order to further clarify the source of soluble receptor in serum and to determine whether release of receptor from rat tissues is under developmental regulation, receptor release from rat explants was examined and compared to serum levels of receptor. Heart, skeletal muscle, kidney, and liver explants from fetal, neonatal, weanling, and adult rats were cultured in serum-free medium, and the conditioned medium was analyzed by RIA for the presence of receptor. Soluble receptor release was highest for fetal and neonatal tissues, with weanling and adult tissues showing dramatically decreased levels. Release of soluble receptor varied between tissues, with the tissue-specific pattern altering during development, such that while heart and muscle appeared as major tissues of release in fetal animals, the liver was the tissue of highest release in adult animals. It is concluded that release of soluble receptor by rat tissues is developmentally regulated, with levels of receptor in serum reflecting the pattern of release from tissues. The RIA will prove a useful tool for further examination of the regulation and function of the soluble insulin-like growth factor-II/mannose 6-phosphate receptor." @default.
- W4235206572 created "2022-05-12" @default.
- W4235206572 creator A5060018594 @default.
- W4235206572 date "1992-06-01" @default.
- W4235206572 modified "2023-10-14" @default.
- W4235206572 title "Radioimmunoassay of soluble insulin-like growth factor-II/mannose 6- phosphate receptor: developmental regulation of receptor release by rat tissues in culture" @default.
- W4235206572 doi "https://doi.org/10.1210/en.130.6.3387" @default.
- W4235206572 hasPublicationYear "1992" @default.
- W4235206572 type Work @default.
- W4235206572 citedByCount "1" @default.
- W4235206572 crossrefType "journal-article" @default.
- W4235206572 hasAuthorship W4235206572A5060018594 @default.
- W4235206572 hasConcept C126322002 @default.
- W4235206572 hasConcept C134018914 @default.
- W4235206572 hasConcept C144174609 @default.
- W4235206572 hasConcept C170493617 @default.
- W4235206572 hasConcept C172680121 @default.
- W4235206572 hasConcept C176685330 @default.
- W4235206572 hasConcept C202751555 @default.
- W4235206572 hasConcept C21936154 @default.
- W4235206572 hasConcept C2775960820 @default.
- W4235206572 hasConcept C2776205754 @default.
- W4235206572 hasConcept C2778433245 @default.
- W4235206572 hasConcept C2779234561 @default.
- W4235206572 hasConcept C2779244956 @default.
- W4235206572 hasConcept C54355233 @default.
- W4235206572 hasConcept C55493867 @default.
- W4235206572 hasConcept C71924100 @default.
- W4235206572 hasConcept C86803240 @default.
- W4235206572 hasConceptScore W4235206572C126322002 @default.
- W4235206572 hasConceptScore W4235206572C134018914 @default.
- W4235206572 hasConceptScore W4235206572C144174609 @default.
- W4235206572 hasConceptScore W4235206572C170493617 @default.
- W4235206572 hasConceptScore W4235206572C172680121 @default.
- W4235206572 hasConceptScore W4235206572C176685330 @default.
- W4235206572 hasConceptScore W4235206572C202751555 @default.
- W4235206572 hasConceptScore W4235206572C21936154 @default.
- W4235206572 hasConceptScore W4235206572C2775960820 @default.
- W4235206572 hasConceptScore W4235206572C2776205754 @default.
- W4235206572 hasConceptScore W4235206572C2778433245 @default.
- W4235206572 hasConceptScore W4235206572C2779234561 @default.
- W4235206572 hasConceptScore W4235206572C2779244956 @default.
- W4235206572 hasConceptScore W4235206572C54355233 @default.
- W4235206572 hasConceptScore W4235206572C55493867 @default.
- W4235206572 hasConceptScore W4235206572C71924100 @default.
- W4235206572 hasConceptScore W4235206572C86803240 @default.
- W4235206572 hasIssue "6" @default.
- W4235206572 hasLocation W42352065721 @default.
- W4235206572 hasOpenAccess W4235206572 @default.
- W4235206572 hasPrimaryLocation W42352065721 @default.
- W4235206572 hasRelatedWork W1965570643 @default.
- W4235206572 hasRelatedWork W1995476527 @default.
- W4235206572 hasRelatedWork W1998465328 @default.
- W4235206572 hasRelatedWork W2002562299 @default.
- W4235206572 hasRelatedWork W2016564814 @default.
- W4235206572 hasRelatedWork W2039466440 @default.
- W4235206572 hasRelatedWork W2055417699 @default.
- W4235206572 hasRelatedWork W2102298564 @default.
- W4235206572 hasRelatedWork W2103096725 @default.
- W4235206572 hasRelatedWork W2126532023 @default.
- W4235206572 hasVolume "130" @default.
- W4235206572 isParatext "false" @default.
- W4235206572 isRetracted "false" @default.
- W4235206572 workType "article" @default.