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- W4235256619 abstract "Psoriasis is an immune-mediated skin disease in which T cells initiate and maintain the pathogenic process. 1 T cells become activated, migrate into the skin, and induce the keratinocyte proliferation associated with the psoriatic phenotype. The activated T cells that infiltrate the skin express the memory phenotype (CD45RO + ). 2,3 Both CD4 + and CD8 + memory T-cell subtypes are believed to play a role in the pathogenesis of psoriasis. The effectiveness of many traditional therapies for psoriasis (e.g., cyclosporine, methotrexate, psoralen/ultraviolet A light) can be attributed, at least in part, to the potent immunosuppressive effects of these treatments. 4,5 Unfortunately, a lack of selective targeting of the immune system by these therapies may result in treatment-limiting side effects." @default.
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- W4235256619 date "2004-12-01" @default.
- W4235256619 modified "2023-09-23" @default.
- W4235256619 title "Introduction" @default.
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- W4235256619 doi "https://doi.org/10.1177/12034754040080s201" @default.
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