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- W4235288776 abstract "We have studied the time- and dose-dependent effects of S9977-2 versus tacrine (THA) on psychomotor activity (PMA) and passive avoidance learning (PAL) in intact 3-month-old rats. No significant changes were observed in the levels of PMA in animals tested 0, 30 and 60 min after i.p. injections of S9977-2 (0·125 mg/kg) or THA (1 mg/kg). In a PAL maze paradigm, S9977-2 and THA, administered 30, 60 and 120 min before testing, induced time-dependent improvements in learning indices, with maximum effects during the first hour after administration. In the dose–response study, S9977-2 (0·005, 0·025 and 0·125 mg/kg) tended to increase and THA (0·33, 1 and 3 mg/kg) to decrease PMA scores while the two compounds improved learning in a progressive dose-related manner. The present results indicate that S9977-2 and THA exert opposite actions on exploratory behaviour, S9977-2 increasing this parameter and THA decreasing it, and that both molecules improve learning in a similar time- and dose-dependent manner. On a molar basis S9977-2 is 10–20 times more potent than THA in enhancing learning acquisition. © 1997 John Wiley & Sons, Ltd." @default.
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- W4235288776 date "1997-07-01" @default.
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- W4235288776 title "Comparative effects of S9977-2 versus tacrine on passive avoidance learning and psychomotor activity" @default.
- W4235288776 doi "https://doi.org/10.1002/(sici)1099-1077(199707/08)12:4<329::aid-hup867>3.3.co;2-t" @default.
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