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• W4235311411 abstract "CorrigendumCorrigendumPublished Online:15 Oct 2012https://doi.org/10.1152/ajpcell.zh0-7089-corr.2012Original articleMoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Volume 303, September 2012Volume 72, September 2012Calve S, Isaac J, Gumucio JP, Mendias CL. Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy. Am J Physiol Cell Physiol 303: , 2012. First published July 11, 2012; doi:10.1152/ajpcell.00057.2012 (http://ajpcell.physiology.org/content/303/5/C577).—In results, Figs. 8 and 9 were presented incorrectly. The corrected Figs. 8 and 9 appear below. In addition, in the section entitled “Differential expression of MMPs,” the first sentence should read as “The expression pattern of MMP-2 suggests that it plays a role during hypertrophic growth (Fig. 9).”Fig. 8.HAS1–HAS3 and the hyaluronidases are differentially expressed in response to hypertrophic overload. A and B: HAS1 and HAS2 were significantly upregulated in response to tenectomy with HAS1 displaying an additional effect of time. C–E: HAS3 and Hyal2 in overloaded muscles did not vary from controls at any time point, whereas Hyal1 was slightly, but significantly, increased in response to tenectomy. F: two-way ANOVA was performed on overloaded and control muscles within each primer set to determine the effect of time and tenectomy on gene expression. Bonferroni's post hoc test was utilized to assess significant differences in relative copy number between control and tenectomy and time after tenectomy (*P < 0.05). Data from overloaded plantaris were normalized to age-matched controls and, for each time point after tenectomy, control values were plotted on the left and overloaded on the right (black bars). Values are presented as means ± SD; n ≥ 3 mice.Download figureDownload PowerPointFig. 9.MMPs and their regulators TIMP1 and TIMP2 are differentially expressed in response to hypertrophic overload. A: MMP2 expression was initially suppressed at 2 days and then increased by 14 days with a 5.8-fold upregulation compared with controls. B: in contrast, MMP9 showed the greatest upregulation at 2 days and decreased to control values at 7 and 14 days. C: similar to MMP2, MMP14 expression was enhanced 1.2- to 11.3-fold between 2–14 days. D and E: 2 MMP regulators, TIMP1 and TIMP2 displayed reverse trends in expression where TIMP1 was greatly upregulated at 2 days and significantly decreased from 98- to 41-fold upregulation and TIMP2 was more modestly expressed, increasing from baseline values to 2.6-fold over controls by 14 days. F: two-way ANOVA was performed on overloaded and control muscles within each primer set to determine the effect of time and tenectomy on gene expression. Bonferroni's post hoc test was utilized to assess significant differences in relative copy number between control and tenectomy and time after tenectomy (*P < 0.05). Data from overloaded plantaris were normalized to age-matched controls and, for each time point after tenectomy, control values were plotted on the left and overloaded on the right (black bars). Values are presented as means ± SD; n ≥ 3 mice.Download figureDownload PowerPointThis article has no references to display. Download PDF Previous Back to Top FiguresReferencesRelatedInformationRelated ArticlesHyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy 01 Sep 2012American Journal of Physiology-Cell Physiology More from this issue > Volume 303Issue 8October 2012Pages C895-C896 Copyright & PermissionsCopyright © 2012 the American Physiological Societyhttps://doi.org/10.1152/ajpcell.zh0-7089-corr.2012History Published online 15 October 2012 Published in print 15 October 2012 Metrics" @default.
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